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Pregled bibliografske jedinice broj: 741050

Časopis

Autori: Milković, Lidija; Čipak Gašparović, Ana; Žarković, Neven
Naslov: Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor
Izvornik: Free radical research (1071-5762) 49 (2015), 7; 850-860
Vrsta rada: pregledni rad
Ključne riječi: cell proliferation; growth regulation; hormesis; lipid peroxidation; oxidative stress
Sažetak:
The reactive aldehyde 4-hydroxynonenal (HNE) is major bioactive marker of lipid peroxidation generated under oxidative stress from polyunsaturated fatty acids. Biomedical significance of HNE was first revealed in pathogenesis of various degenerative and malignant diseases. Thus, HNE was considered for decades only as cytotoxic molecule, “second toxic messenger of free radicals” responsible for numerous undesirable consequences of oxidative stress. However, the increase of knowledge on physiology of redox signaling revealed also desirable, physiological roles of HNE, especially in the field of cellular signaling pathways regulating proliferation, differentiation, and apoptosis. These pluripotent effects of HNE can be explained by its concentration-dependent interactions with the cytokine networks and complex cellular antioxidant systems also showing cell and tissue specificities. Therefore, this paper gives a comprehensive, yet short overview on HNE as pluripotent growth-regulating factor.
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://www.tandfonline.com/doi/full/10.3109/10715762.2014.999056
http://dx.doi.org/10.3109/10715762.2014.999056
Broj citata:
Altmetric:
DOI: 10.3109/10715762.2014.999056
URL cjelovitog teksta:
Google Scholar: Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth regulating factor
Upisao u CROSBI: Marina Štoser (mstroser@mef.hr), 15. Pro. 2014. u 10:53 sati



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