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Pregled bibliografske jedinice broj: 74904

Časopis

Autori: Poljak-Blaži, Marija; Katić, Maša; Kralj, Marijeta; Žarković, Neven; Marotti, Tanja; Bošnjak, Berislav; Šverko, Višnja; Balog, Tihomir; Pavelić, Krešimir
Naslov: In vitro and in vivo effect of natural clinoptilolite on malignant tumors
Izvornik: Studies in Surface Science and Catalysis (0167-2991) 135 (2001); 5309-5316
Vrsta rada: članak
Ključne riječi: natural clinoptilolite; tumor
Sažetak:
Many biochemical processes are closely related to ion change, adsorption and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide, they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. In vitro experiments showed inhibition of tumor cell proliferation as well as MZ to be the possible scavenger of HNE. After i.p. application of MZ, the number of peritoneal macrophages was increased as well as their production of oxide anion. NO generation was totally abolished. At te same time translocationof p65 subunit of NF-kapaB in spleen cells was observed. Thus, here we report anticancer effect of MZ in vitro and immunostimulatory effect in vivo. We also propose possible mechanism of its action in vivo.
Projekt / tema: 00981104, 00981107, 00981113
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: In vitro and in vivo effect of natural clinoptilolite on malignant tumors



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