Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 74905

Zbornik radova

Autori: Poljak-Blaži, Marija; Katić, Maša; Kralj, Marijeta; Žarković, Neven; Marotti, Tanja; Bošnjak, Berislav; Šverko, Višnja; Balog, Tihomir; Pavelić, Krešimir
Naslov: In vitro and in vivo effect of natural clinoptilolite on malignant tumors
Izvornik: Proceedings of the 13th International Zeolite Conference "Zeolites and Mesoporous Materials at the Dawn of the 21st Century" ; Studies in surface science and catalysis ; Vol. 135 / Galarneau, A. ; di Renzo, F. ; Fajula, F. ; Vedrine, J. (ur.). - Amsterdam : Elsevier , 2001. 374-374 (ISBN: 978-0-444-50238-4).
Skup: International Zeolite Conference (13 ; 2001)
Mjesto i datum: Montpellier, Francuska, 08.-13.07.2001.
Ključne riječi: natural clinoptilolite; tumor
Sažetak:
Many biochemical processes are closely related to ion change, adsorption and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide, they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interesting for pharmaceutical industry and medicine. In vitro experiments showed inhibition of tumor cell proliferation as well as MZ to be the possible scavenger of HNE. After i.p. application of MZ, the number of peritoneal macrophages was increased as well as their production of oxide anion. NO generation was totally abolished. At te same time translocationof p65 subunit of NF-kapaB in spleen cells was observed. Thus, here we report anticancer effect of MZ in vitro and immunostimulatory effect in vivo. We also propose possible mechanism of its action in vivo.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 00981113, 00981107, 00981104
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti