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Pregled bibliografske jedinice broj: 75235

Časopis

Autori: Pavelić, Krešimir; Hadžija, Mirko; Bedrica, Ljiljana; Pavelić, Jasminka; Đikić, Ivan; Katić, Maša; Kralj, Marijeta; Herak Bosnar, Maja; Kapitanović, Sanja; Poljak-Blaži, Marija; Križanac, Šimun; Stojković, Ranko; Jurin, Mislav; Subotić, Boris; Čolić, Miroslav
Naslov: Natural zeolite clinoptilolite: new adjuvant in anticancer therapy
Izvornik: Journal of Molecular Medicine (0946-2716) 78 (2001), 12; 708-720
Vrsta rada: članak
Ključne riječi: clinoptilolite; adjuvant; anticancer; treatment
Sažetak:
Natural silicate materials, including zeolite clinoptilolite, have been shown to exhibit diverse biological activities and have been used successfully as a vaccine adjuvant and for the treatment of diarrhea. We report a novel use of finely ground clinoptilolite as a potential adjuvant in anticancer therapy. Clinoptilolite treatment of mice and dogs suffering from a variety of tumor types led to improvement in the overall health status, prolongation of life-span, and decrease in tumors size. Local application of clinoptilolite to skin cancers of dogs effectively reduced tumor formation and growth. In addition, toxicology studies on mice and rats demonstrated that the treatment does not have negative effects. In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cencer cell lines. These data indicate that clinoptilolite treatment might affect cancer growth by attenuating survival signals and inducing tumor suppressor genes in treated cells.
Projekt / tema: 0053333, 108122, 101751, 00981113, 00981111, 00981110, 00981109, 00981104, 00981103, 00980901
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T6P-436FD9W-9-9&_cdi=5036&_user=3875467&_orig=search&_coverDate=07%2F31%2F2001&_sk=999609992&view=c&wchp=dGLbVzb-zSkWb&md5=de2e03c263f3d0d4f911d04681ef692f&ie=/sdarticle.pdf
URL cjelovitog teksta:
Google Scholar: Natural zeolite clinoptilolite: new adjuvant in anticancer therapy



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