crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 755019

Časopis

Autori: Zarkovic, Kamelija; Larroque-Cardoso, Pauline; Pucelle, Mellanie; Salvayre, Robert; Waeg, Georg; Nègre-Salvayre, Anne; Zarkovic, Neven
Naslov: Elastin aging and lipid oxidation products in human aorta
Izvornik: Redox Biology (2213-2317) 4 (2015); 109-117
Vrsta rada: članak
Ključne riječi: 4-hydroxynonenal; Elastin; Atherosclerosis; Smooth muscle cells; Extracellular matrix; Aging
Sažetak:
Vascular aging is associated with structural and functional modifications of the arteries, and by an increase in arterial wall thickening in the intima and the media, mainly resulting from structural modifications of the extracellular matrix (ECM) components. Among the factors known to accumulate with aging, advanced lipid peroxidation end products (ALEs) are a hallmark of oxidative stress-associated diseases such as atherosclerosis. Aldehydes generated from the peroxidation of polyunsaturated fatty acids (PUFA), (4-hydroxynonenal, malondialdehyde, acrolein), form adducts on cellular proteins, leading to a progressive protein dysfunction with consequences in the pathophysiology of vascular aging. The contribution of these aldehydes to ECM modification is not known. This study was carried out to investigate whether aldehyde-adducts are detected in the intima and media in human aorta, whether their level is increased in vascular aging, and whether elastin fibers are a target of aldehyde-adduct formation. Immunohistological and confocal immunofluorescence studies indicate that 4-HNE-histidine-adducts accumulate in an age-related manner in the intima, media and adventitia layers of human aortas, and are mainly expressed in smooth muscle cells. In contrast, even if the structure of elastin fiber is strongly altered in the aged vessels, our results show that elastin is not or very poorly modified by 4-HNE. These data indicate a complex role for lipid peroxidation and in particular for 4-HNE in elastin homeostasis, in the vascular wall remodeling during aging and atherosclerosis development.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biotehnologija
URL Internet adrese: http://fulir.irb.hr/2817/1/RedoxBiology_4_2015_109_117.pdf
http://www.sciencedirect.com/science/article/pii/S2213231714001323#fx1
Broj citata:
Altmetric:
DOI: 10.1016/j.redox.2014.12.008
URL cjelovitog teksta:
Google Scholar: Elastin aging and lipid oxidation products in human aorta
Upisao u CROSBI: Marina Štoser (mstroser@mef.hr), 12. Ožu. 2015. u 14:40 sati



  Verzija za printanje   za tiskati


upomoc
foot_4