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Pregled bibliografske jedinice broj: 755384

Časopis

Autori: Tariba, Blanka; Živković, Tanja; Krasnići, Nesrete, Filipović Marijić, Vlatka; Erk, Marijana; Gamulin, Marija; Grgić, Mislav; Pizent, Alica
Naslov: Serum metallothionein in patients with testicular cancer
( Serum metallothionein in patients with testicular cancer )
Izvornik: Cancer chematotherapy and pharmacology (0344-5704) 75 (2015), 4; 813-820
Vrsta rada: članak
Ključne riječi: Testicular cancer; Metallothionein; Platinum; Serum marker
( Testicular cancer; Metallothionein; Platinum; Serum marker )
Sažetak:
Metallothioneins (MTs) have been disclosed as a useful diagnostic factor for tumour progression and drug resistance in a variety of malignancies. Increased levels of MT in blood serum have been found in patients with several types of cancer, but there is no available information on serum MT levels in patients with testicular germ cell tumour (TGCT). The aim of the study was to determine MT levels in serum of patients with TGCT and to evaluate the portion of platinum (Pt) that binds to MT after cisplatin administration since MTs could be involved in drug resistance. Methods: Concentration of total MT was determined in serum of 25 men with newly diagnosed TGCT by differential pulse voltammetry. The fractionation of serum was carried out by size exclusion high-performance liquid chromatography (SE-HPLC), while concentration of Pt in collected fractions was determined by inductively coupled plasma mass spectrometry. Results: Concentration of serum MT was significantly higher in TGCT patients than in healthy volunteers. The results of SE- HPLC analysis showed that only a small amount of Pt was bound to proteins in the area of MT elution. Conclusions: Significant increase in MT levels in individuals with TGCT indicates certain health problem and, in combination with other commonly used diagnostic tools, could improve early diagnosis.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://link.springer.com/article/10.1007%2Fs00280-015-2702-2
Broj citata:
Altmetric:
DOI: 10.1007/s00280-015-2702-2
URL cjelovitog teksta:
Google Scholar: Serum metallothionein in patients with testicular cancer
Upisao u CROSBI: Blanka Tariba (btariba@imi.hr), 16. Ožu. 2015. u 09:44 sati



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