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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 756018

Časopis

Autori: Kralj, Marijeta; Uzelac, Lidija; Wang, Yu-Hsuan; Wan, Peter; Tireli, Martina; Mlinarić-Majerski, Kata; Piantanida, Ivo; Basarić, Nikola
Naslov: Enhancement of antiproliferative activity by phototautomerization of anthrylphenols
Izvornik: Photochemical & photobiological sciences (1474-905X) 14 (2015), 6; 1082-1092
Vrsta rada: članak
Ključne riječi: anthracenes ; antiproliferative activity ; excited state proton trasnfer ; quinone methides
Sažetak:
Antiproliferative investigation has been conducted on 3 human cancer cell lines HCT 116 (colon), MCF-7 (breast), and H 460 (lung), on a series of 4 anthrylphenols in dark, and upon exposure to light (350 nm). 9-(2-Hydroxyphenyl)anthracene (1) moderately inhibits the proliferation, but the irradiation considerably enhances the effect. The other investigated anthracenes 4-6 exhibit antiproliferative activity in dark, which was not enhanced upon irradiation. The enhancement of the antiproliferative effect on irradiation of 1 was rationalized as being due to the formation of quinone methide (QM 2) by excited state proton transfer. QM 2 acts as an electrophilic species capable of reacting with biological molecules. Although QM 2 reacts with nucleotides, adducts could not be isolated. On the contrary, cysteine adduct 8 has been isolated and characterized, whereas adducts with glycine, serine and tripeptide glutathione have been characterized by MS. Non-covalent binding of 1 to DNA and bovine serum albumin was demonstrated by UV-vis, fluorescence and CD spectroscopy. However, straightforward conclusion about the DNA or ptotein alkylating (damaging) ability of 2 could not be drawn. The results obtained by the irradiations of 1 in the presence of DNA, amino acids and peptides, the cell cycle perturbation analysis, and in vitro translation of GFP suggest that the effect is not only due to the damage of DNA but also the impact on the cellular proteins. Considering that up to date all QM agents were assumed to target dominantly DNA, this is an important finding with impact to the further development of anticancer agents based on QMs.
Projekt / tema: HRZZ-IP-2013-11-5660, 098-0982914-2918, 098-0982464-2514, 02.05/25
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://pubs.rsc.org/en/Content/ArticleLanding/2015/PP/C5PP00099H#!divAbstract
http://pubs.rsc.org/en/content/articlehtml/2015/pp/c5pp00099h
Broj citata:
Altmetric:
DOI: 10.1039/c5pp00099h
URL cjelovitog teksta:
Google Scholar: Enhancement of antiproliferative activity by phototautomerization of anthrylphenols
Upisao u CROSBI: Enidija Lukša (Enidija.Luksa@irb.hr), 23. Ožu. 2015. u 10:46 sati



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