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Pregled bibliografske jedinice broj: 76448

Zbornik radova

Autori: Dogan Koružnjak, Jasna; Slade, Neda; Zamola, Branimir; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones
Izvornik: Knjiga sinopsisa / Prous, J.R. (ur.). - Barcelona : Drugs of the Future , 2002. 209-209.
Skup: XVII International Symposium on Medicinal chemistry
Mjesto i datum: Barcelona, Španjolska, 01-05.09.2002.
Ključne riječi: thienothienil quinolons; antitumor activity
Sažetak:
Some new polycyclic heterocyclic compounds of the quinolone type shown on Figure 1 were prepared by multistep synthesis [1]. Common feature of all the compounds synthesized is that they have at least one N-[3-(dimethylamino)propyl] group which is present in number of substances possessing antiviral activity [2]. R R’ -H -(CH2)3N(CH3)2 -COOCH3 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -(CH2)3N(CH3)2 -CONHC6H5 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -H -CON(C6H5)(CH2)3N(CH3)2 -H Figure 1. Structure of thieno[3’, 2’:4, 5]thieno[2, 3-c]quinolin-6-ones The reaction of photocyclization of anilides, acylation of amines with carboxylic chlorides and esters and N-alkylation of amides were used as a final step in the synthesis of corresponding quinolone derivatives. Prepared quinolones were tested on antitumor activity and showed very intensive action “in vitro” on some human carcinoma [3]. Testing “in vivo” is in course.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0098092, 0098093, 00981103, 00981104, 0125005
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita



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