Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones (CROSBI ID 482921)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace
engleski
Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones
Some new polycyclic heterocyclic compounds of the quinolone type shown on Figure 1 were prepared by multistep synthesis [1]. Common feature of all the compounds synthesized is that they have at least one N-[3-(dimethylamino)propyl] group which is present in number of substances possessing antiviral activity [2]. R R -H -(CH2)3N(CH3)2 -COOCH3 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -(CH2)3N(CH3)2 -CONHC6H5 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -H -CON(C6H5)(CH2)3N(CH3)2 -H Figure 1. Structure of thieno[3, 2:4, 5]thieno[2, 3-c]quinolin-6-ones The reaction of photocyclization of anilides, acylation of amines with carboxylic chlorides and esters and N-alkylation of amides were used as a final step in the synthesis of corresponding quinolone derivatives. Prepared quinolones were tested on antitumor activity and showed very intensive action in vitro on some human carcinoma [3]. Testing in vivo is in course.
thienothienil quinolons; antitumor activity
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Podaci o prilogu
209-209-x.
2002.
objavljeno
Podaci o matičnoj publikaciji
Knjiga sinopsisa
Prous, J.R.
Barcelona: Drugs of the Future
Podaci o skupu
XVII International Symposium on Medicinal chemistry
poster
01.09.2002-05.09.2002
Barcelona, Španjolska