Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones (CROSBI ID 482921)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones // Knjiga sinopsisa / Prous, J.R. (ur.). Barcelona: Drugs of the Future, 2002. str. 209-209-x

Podaci o odgovornosti

Dogan Koružnjak, Jasna ; Slade, Neda ; Zamola, Branimir ; Pavelić, Krešimir ; Karminski-Zamola, Grace

engleski

Synthesis of some new biologically active thieno[3, 2-b:4, 5-b']thieno-[2, 3-c]quinolones

Some new polycyclic heterocyclic compounds of the quinolone type shown on Figure 1 were prepared by multistep synthesis [1]. Common feature of all the compounds synthesized is that they have at least one N-[3-(dimethylamino)propyl] group which is present in number of substances possessing antiviral activity [2]. R R’ -H -(CH2)3N(CH3)2 -COOCH3 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -(CH2)3N(CH3)2 -CONHC6H5 -(CH2)3N(CH3)2 -CONH(CH2)3N(CH3)2 -H -CON(C6H5)(CH2)3N(CH3)2 -H Figure 1. Structure of thieno[3’, 2’:4, 5]thieno[2, 3-c]quinolin-6-ones The reaction of photocyclization of anilides, acylation of amines with carboxylic chlorides and esters and N-alkylation of amides were used as a final step in the synthesis of corresponding quinolone derivatives. Prepared quinolones were tested on antitumor activity and showed very intensive action “in vitro” on some human carcinoma [3]. Testing “in vivo” is in course.

thienothienil quinolons; antitumor activity

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

209-209-x.

2002.

objavljeno

Podaci o matičnoj publikaciji

Knjiga sinopsisa

Prous, J.R.

Barcelona: Drugs of the Future

Podaci o skupu

XVII International Symposium on Medicinal chemistry

poster

01.09.2002-05.09.2002

Barcelona, Španjolska

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita