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Pregled bibliografske jedinice broj: 779925

Zbornik radova

Autori: Lalić, Jasna; Mikoč, Andreja; Perina, Dragutin; Sabljić, Igor; Pleše, Bruna; Imešek, Mirna; Ćetković, Helena; Luić, Marija; Žaja, Roko; Ahel, Ivan
Naslov: Macrodomain protein from bacterium Streptomyces coelicolor
Izvornik: Congress of the Croatian Society of Biochemistry and Molecular Biology “The Interplay of Biomolecules” (HDBMB2014) : book of abstracts / Katalinić, Maja ; Kovarik, Zrinka (ur.). - Zagreb : Croatian Society of Biochemistry and Molecular Biology , 2014. 107-107 (ISBN: 978-953-95551-5-1).
Skup: Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules"
Mjesto i datum: Zadar, Hrvatska, 24-27.09. 2014
Ključne riječi: DNA damage response; Macrodomain; Poly(ADP‐ribose)
Sažetak:
Macrodomains are evolutionary conserved structural domains that bind ADP-ribose derivatives found in proteins with diverse cellular functions. Some proteins from the macrodomain family (human MacroD1, MacroD2) can hydrolyze ADP-ribosylated substrates and therefore reverse posttranslational modification - ADP-ribosylation in which an ADP-ribose moiety from NAD+ is transferred to a target protein. ADP-ribosylation can alter the physical and chemical properties of target proteins and controls many important cellular processes. Bacteria, and Streptomyces in particular, are known to utilize protein ADP- ribosylation to control a variety of important pathways (such as morphological differentiation and antibiotic production). We have determined crystal structure and biochemically and functionally characterized a macrodomain protein form bacterium Streptomyces coelicolor. This protein is a member of an uncharacterised subfamily of macrodomain proteins. Its crystal structure revealed highly conserved macrodomain fold. This macrodomain protein is involved in the DNA damage response, while knockout strain shows a conditional effect on antibiotic production. Our results give us a first insight into the molecular basis of its action, involvement in ADP-ribosylation cycle and impact on Streptomyces metabolism.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Biologija
Upisao u CROSBI: Helena Ćetković (Helena.Cetkovic@irb.hr), 5. Lis. 2015. u 12:30 sati



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