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Pregled bibliografske jedinice broj: 783295

Zbornik radova

Autori: Tariba, Blanka; Krasnići, Nesrete; Živković, Tanja; Filipović Marijić, Vlatka; Erk, Marijana; Pizent, Alica
Naslov: Effect of Pt-based chemotherapy on bioavailability of trace elements in serum of men with testicular cancer
( Effect of Pt-based chemotherapy on bioavailability of trace elements in serum of men with testicular cancer )
Izvornik: Journal of Trace Elements in Medicine and Biology, Abstracts XI. ISTERH Conference, Recent Advances in Trace Element Research in Health and Disease / Jurasović, Jasna ; Aschner, Michael (ur.). - The Netherlands : Elsevier GmbH , 2015. 36-36.
ISSN: 0946-672X
Skup: XI. ISTERH Conference, A joint conference with Nordic Trace Element Society (NTES) and Croatian Society for Biochemistry and Molecular Biology
Mjesto i datum: Dubrovnik, Hrvatska, 18-22.10.2015.
Ključne riječi: chemotherapy; essential elements; platinum; serum
( chemotherapy; essential elements; platinum; serum )
Sažetak:
Large amounts of Pt introduced into an organism during Pt-based chemotherapy may affect the bioavailability of other trace elements. We determined the concentration of Cu, Se, Zn, As, Cd, Pb and Pt in serum of 55 patients with testicular cancer before and after Pt-based chemotherapy, as well as basic distribution of these elements among serum protein fractions. The results show significant decrease of serum Cu, Se, Zn and Pb, and significant increase of Pt after chemotherapy. Distribution profiles of Pt, Se and Zn among serum protein fractions include a dominant peak obtained at the elution time of 24 min corresponding to the medium molecular mass (MMM) proteins, and is most likely related to albumin. The results suggest that Pt competes with Se and Zn for the same binding sites in MMM proteins which affect their bioavailability. The imbalance between trace elements could lead to increased sensitivity and to resistance to treatment resulting in slower recovery of patients.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 98, 22
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
Upisao u CROSBI: Blanka Tariba (btariba@imi.hr), 27. Lis. 2015. u 10:06 sati



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