Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 790232

Zbornik radova

Autori: Fuller, Heidi R.; Slade, Robert; Jovanov- Milošević, Nataša; Babić, Mirjana; Sedmak, Goran; Šimić, Goran; Fuszard, Matthew A.; Shirran, Sally L.; Botting, Catherine H.; Gates, Monte A.
Naslov: Quantitative proteomics reveals that stathmin - a microtubule destabilising protein – is highly enriched in the developing corticospinal system
Izvornik: Book of abstracts of the FENS Featured Regional Meeting 2015
Skup: FENS Featured Regional Meeting 2015
Mjesto i datum: Thessaloniki, Grčka, 7-10.10.2015.
Ključne riječi: Corticospinal tract; stathmin; developing brain
Sažetak:
The mammalian corticospinal tract (CST) is the longest efferent axonal projection in the central nervous system, originating from upper motor neurons in layer V of the cortex. Little, though, is known about the proteins that are important to the growth of corticospinal neurons down the spinal cord. This is unfortunate because regeneration of the CST is of great therapeutic importance. There are an estimated 6, 500 cases of spinal cord injury (SCI) per year in Western Europe, and between 100, 000-200, 000 incidences worldwide. One hope is that by identifying key intracellular and extracellular proteins involved in the development and growth of the corticospinal system, the regeneration of the mature CST might be enhanced by manipulating these developmental constituents. The aim of this study, therefore, was to conduct a comprehensive temporal and spatial quantitative proteomics analysis of the rat CST during its formation.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: IP-2014-09-9730, HRZZ-09/16
Izvorni jezik: ENG
Kategorija: Ostalo
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Goran Šimić (gsimic@hiim.hr), 15. Pro. 2015. u 18:02 sati