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Pregled bibliografske jedinice broj: 803581

Časopis

Autori: Wittine, Karlo; Ratkaj, Ivana; Benci, Krešimir; Suhina, Tomislav; Mandić, Leo; Ilić, Nataša; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Mintas, Mladen
Naslov: The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations
Izvornik: Medicinal chemistry research (1054-2523) 25 (2016), 4; 728-737
Vrsta rada: članak
Ključne riječi: coumarin[3; 2-c]thiophene; urea; hydroxamic acid; antitumour
Sažetak:
In the present paper, we report on the synthesis and in vitro anti-tumour effects of novel hydroxamic acid (compounds 4 and 5) and ureido (compounds 7-11) derivatives containing coumarin[3, 2-c]thiophene moiety. The results of anti-proliferative assays performed on a panel of selected human tumour cell lines revealed stronger concentration-dependent anti-proliferative activity of coumarin[3, 2-c]thiophene (7-11) ureido derivatives in comparison with coumarin[3, 2-c]thiophene hydroxamic acid derivatives (4 and 5). Nevertheless, compounds 7-10 were cytotoxic on normal human fibroblasts as well. Importantly, the ureido derivative 11 and hydroxamic acid derivatives 4 and 5 showed pronounced and selective inhibitory activity towards cervical carcinoma (HeLa) cell line with concomitant low or no cytotoxicity on normal human fibroblasts. These compounds can therefore be considered as potential anti-tumour lead compounds for further structural optimization.
Projekt / tema: 13.11.1.2.01, 13.11.1.1.11, 335-0000000-3532, 335-0982464-2393, 125-0982464-2922
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biotehnologija
URL Internet adrese: http://link.springer.com/article/10.1007/s00044-016-1523-0?wt_mc=internal.event.1.SEM.ArticleAuthorAssignedToIssue
http://link.springer.com/article/10.1007%2Fs00044-016-1523-0
Broj citata:
Altmetric:
DOI: 10.1007/s00044-016-1523-0
URL cjelovitog teksta:
Google Scholar: The novel coumarin[3, 2-c]thiophene and its hydroxamic acid and ureido derivatives : synthesis and cytostatic activity evaluations
Upisao u CROSBI: Karlo Wittine (karlo.wittine@biotech.uniri.hr), 1. Ožu. 2016. u 10:19 sati



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