crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 806161

Časopis

Autori: Senta, Ivan; Krizman, Ivona; Ahel, Marijan; Terzic, Senka
Naslov: Multriresidual analysis of emerging amphetamine-like psychoactive substances in wastewater and river water
( Multriresidual analysis of emerging amphetamine-like psychoactive substances in wastewater and river water )
Izvornik: Journal of chromatography. A (0021-9673) 1425 (2015); 204-212
Vrsta rada: članak
Ključne riječi: novel psychoactive substances ; designer drugs ; illicit drugs ; amphetamine ; wastewater ; liquid chromatography-tandem massspectrometry
( novel psychoactive substances ; designer drugs ; illicit drugs ; amphetamine ; wastewater ; liquid chromatography-tandem massspectrometry )
Sažetak:
Besides the common illicit drugs, such as cocaine, heroin, and marijuana, there is a growing concernabout the use of modern “designer drugs” that have emerged in large numbers over the past fewyears. In this work, a sensitive and selective method for simultaneous determination of 25 syntheticamphetamine-like psychoactive compounds, including amphetamine, sympathomimetic substitutedamphetamines, synthetic cathinones and ketamine, in raw wastewater (RW), secondary effluent (SE)and river water was developed. Samples were enriched by solid-phase extraction (SPE) on mixed-modereversed-phase/strong cation-exchange sorbent (Oasis MCX) and analysed by reversed- phase liquidchromatography coupled to electrospray ionisation tandem mass spectrometry (LC-MS/MS). The targetcompounds were separated on a Synergi Polar column and detected using multiple reaction monitoring(MRM) in positive ionisation mode. Accurate quantification was achieved by using several deuteratedanalogues as surrogate standards. Careful optimisation and validation of the procedure resulted in areliable determination of all target analytes in low ng/L range for all matrices, which makes the methodsuitable for the application in wastewater-based epidemiology. The method was applied for assessment ofselected compounds in municipal wastewater and river water from Croatia. It was shown that most of thewastewater samples contained detectable levels of the well-known synthetic illicit drugs, amphetamineand 3, 4-methylenedioxy- methamphetamine (MDMA) (concentrations up to 545 ng/L and 55 ng/L in RW, respectively), as well as ephedrine (up to 108 ng/L) and pseudoephedrine (up to 698 ng/L), which are usedas ingredients of popular over-the counter cough and cold medications. Other target amphetamine-likepsychoactive substances, recently reported for their potential abuse, were detected only occasionally andin low concentrations (<10 ng/L).
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Geologija
Broj citata:
Altmetric:
DOI: 10.1016/j.chroma.2015.11.043
URL cjelovitog teksta:
Google Scholar: Multriresidual analysis of emerging amphetamine-like psychoactive substances in wastewater and river water
Upisao u CROSBI: Ivan Senta (Ivan.Senta@irb.hr), 16. Ožu. 2016. u 16:52 sati



  Verzija za printanje   za tiskati


upomoc
foot_4