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Pregled bibliografske jedinice broj: 807655

Časopis

Autori: Frijhoff, Jeroen; Winyard, Paul G.; Zarkovic, Neven; Davies, Sean S.; Stocker, Roland; Cheng, David; Knight, Annie R.; Emma Louise Taylor, Oettrich, Jeannette; Ruskovska, Tatjana; Cipak Gasparovic, Ana; Cuadrado, Antonio; Weber, Daniela; Poulsen, Henrik Enghusen; Grune, Tilman; Schmidt, Harald H.H.W.; Ghezzi, Pietro
Naslov: Clinical Relevance of Biomarkers of Oxidative Stress
Izvornik: Antioxidants & redox signaling (1523-0864) 23 (2015), 14; 1144-1170
Vrsta rada: pregledni rad
Ključne riječi: oxidative stress ; biomarker
Sažetak:
Significance: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. Critical Issues: The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use. Future Directions: Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker
Projekt / tema: 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657513/
Broj citata:
Altmetric:
DOI: 10.1089/ars.2015.6317
URL cjelovitog teksta:
Google Scholar: Clinical Relevance of Biomarkers of Oxidative Stress
Upisao u CROSBI: Ana Čipak Gašparović (Ana.Cipak.Gasparovic@irb.hr), 29. Ožu. 2016. u 15:34 sati



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