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Pregled bibliografske jedinice broj: 807819

Časopis

Autori: Jaganjac, Morana; Čipak, Ana; Schaur, Rudolf J.; Žarković, Neven
Naslov: Pathophysiology of neutrophil-mediated extracellular redox reactions
Izvornik: Frontiers in bioscience (1093-9946) 21 (2016); 839-855
Vrsta rada: pregledni rad
Ključne riječi: neutrophils ; reactive oxygen species ; oxidative burst ; 4-hydroxynonenal ; ischemia reperfusion injury ; transplant rejection and chronic diseases
Sažetak:
Neutrophil granulocyte leukocytes (neutrophils) play fundamental role in the innate immune response. In the presence of adequate stimuli, neutrophils release excessive amount of reactive oxygen species (ROS) that may induce cell and tissue injury. Oxidative burst of neutrophils acts as a double-edged sword. It may contribute to the pathology of atherosclerosis and brain injury but is also necessary in resolving infections. Moreover, neutrophil-derived ROS may also have both a tumor promoting and tumor suppressing role. ROS have a specific activities and diffusion distance, which is related to their short lifetime. Therefore, the manner in which ROS will act depends on the cells targeted and the intra- and extracellular levels of individual ROS, which can further cause production of reactive aldehydes like 4-hydroxynonenal (HNE) that act as a second messengers of ROS. In this review we discuss the influence of neutrophil mediated extracellular redox reactions in ischemia reperfusion injury, transplant rejection and chronic diseases (atherosclerosis, inflammatory bowel diseases and cancer). At the end a brief overview of cellular mechanisms to maintain ROS homeostasis is given.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Broj citata:
Altmetric:
DOI: 10.2741/4423
URL cjelovitog teksta:
Google Scholar: Pathophysiology of neutrophil-mediated extracellular redox reactions
Upisao u CROSBI: Lidija Milković (Lidija.Milkovic@irb.hr), 30. Ožu. 2016. u 13:43 sati



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