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Pregled bibliografske jedinice broj: 809654

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Autori: Ćurko-Cofek, Božena; Grubić-Kezele, Tanja; Marinić, Jelena; Tota, Marin; Starčević Čizmarević, Nada; Milin, Čedomila; Ristić, Smiljana; Radošević-Stašić, Biserka; Barac-Latas, Vesna
Naslov: Chronic iron overload induces gender-specific changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
( Chronic iron overload induces gender-specific changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis )
Izvornik: Interactive-program, The 10th International Congress on Autoimmunity, Leipzig
Skup: The 10th International Congress on Autoimmunity
Mjesto i datum: Leipzig, Njemačka, April 6-10, 2016
Ključne riječi: iron overload; EAE; gender
( iron overload; EAE; gender )
Sažetak:
Background/Objectives: Iron is an essential element for cell functions, such as cell proliferation, respiration, folate metabolism and DNA synthesis, having a crucial role in metabolic pathways involved in electron transfer and ATP production. The redox potential of Fe2+/Fe3+ favors its use in a number of protein complexes, but ferrous iron via the Fenton reaction may induce the production of extremely reactive hydroxyl radicals that damage DNA, proteins and lipids. Design/Method: Using experimental autoimmune encephalomyelitis, as an animal model of multiple sclerosis (MS) in this study we analyzed the effects of iron overload on kinetics of disease, iron status and lipid peroxidation. For this purpose female and male DA rats were treated by iron sucrose (75 mg/kg bw/day) or with saline solution during two weeks before the sensitization with bovine brain homogenate in complete Freund's adjuvant. Serum ferritin and tissue contents of iron and malondialdehyde (MDA) were determined in the central nervous system and in the liver on day 13 after immunization. Results: Iron overload in female rats accelerated the onset and first peak of disease, increased the content of ferritin and induced an accumulation of Fe (liver and brain) and MDA (liver). In contrast, in male rats it accelerated the second relapse, augmented iron content (liver) and MDA (spinal cord and brain), and increased the mortality rate. Conclusions: The data point to sexual dimorphism in mechanisms that regulate peripheral and brain iron homeostasis and imply that men and women during MS might be differentially vulnerable to exogenous iron overload.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 13.06.1.1.16, 13.06.1.1.13, 13.06.2.2.61 Sveučilište u Rijeci
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Biserka Radošević-Stašić (biserkars@uniri.hr), 14. Tra. 2016. u 11:58 sati



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