crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 819451

Zbornik radova

Autori: Sambol, Matija; Mlinarić-Majerski, Kata; Basarić, Nikola
Naslov: Synthesis of benzene and naphthalene derivatives of bis(quinone methides)
Izvornik: Simpozij studenata doktorskih studija PMF-aZagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu , 2016. (ISBN: 978-953-6076-39-0).
Skup: Simpozij studenata doktorskih studija PMF-a
Mjesto i datum: Zagreb, Hrvatska, 26.02.2016.
Ključne riječi: quinone methides (QMs) ; anticancer activity ; benzene and naphtalene derivatives
Sažetak:
Some classes of anticancer antibiotics exhibit their antiproliferative activity due to metabolic formation of quinone methides (QMs) that can alkylate biologically important molecules (DNA and enzymes) [1]. However, to date, anticancer activity of simple quinone methides has not been thoroughly investigated, mostly because of their short lifetimes. A photochemical dehydration reaction of suitably substituted phenols provides a very mild and easy approach to QMs in biologically systems [2]. Herein we report synthesis of several bisQMs precursors that are anticipated to induce DNA cross-linking on photoexcitation. Precursors 1 - 10 were prepared by a Grignard reaction of appropriate dibromoalkane and protected benzene or naphthalene o- hydroxycarbaldehyde, which had to be synthesized. The target final bisphenol and bisnaphthol derivatives are new molecules that up to now have not been described in literature so they were characterized by spectroscopic methods. In addition, in vitro antiproliferative activity of the prepared bisQM precursors is going to be investigated.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: HRZZ-IP-2014-09-6312
Izvorni jezik: ENG
Kategorija: Ostalo
Znanstvena područja:
Kemija
Upisao u CROSBI: Enidija Lukša (Enidija.Luksa@irb.hr), 3. Lip. 2016. u 12:47 sati



Verzija za printanje   za tiskati


upomoc
foot_4