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Pregled bibliografske jedinice broj: 820479

Časopis

Autori: Sedić, Mirela; Kraljević Pavelić, Sandra; Cindrić, Mario; Vissers, Johannes; Peronja, Marija; Josić, Djuro; Ćuk, Mario; Fumić, Ksenija; Pavelić, Krešimir; Barić, Ivo
Naslov: Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency
Izvornik: Electrophoresis (0173-0835) 32 (2011), 15; 1970-1975
Vrsta rada: članak
Ključne riječi: S-adenosylhomocysteine hydrolase ; plasma ; proteomics
Sažetak:
S-Adenosylhomocysteine hydrolase (AHCY) deficiency is a rare congenital disorder in methionine metabolism clinically characterized by white matter atrophy, delayed myelination, slowly progressive myopathy, retarded psychomotor development and mildly active chronic hepatitis. In the present study, we utilized a comparative proteomics strategy based on 2-DE/MALDI-MS and LC/ESI-MS to analyze plasma proteins from three AHCY-deficient patients prior to and after receiving dietary treatment designed to alleviate disease symptoms. Obtained results revealed candidate biomarkers for the detection of myopathy specifically associated with AHCY deficiency, such as carbonic anhydrase 3, creatine kinase, and thrombospondin 4. Several proteins mediating T-cell activation and function were identified as well, including attractin and diacylglycerol kinase α. Further validation and functional analysis of identified proteins with clinical value would ensure that these biomarkers make their way into routine diagnosis and management of AHCY deficiency.
Projekt / tema: 108-1081870-1885, 335-0982464-2393, 335-0000000-3532
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1002/elps.201000556/abstract
Broj citata:
Altmetric:
DOI: 10.1002/elps.201000556
URL cjelovitog teksta:
Google Scholar: Plasma biomarker identification in S-adenosylhomocysteine hydrolase deficiency
Upisao u CROSBI: Mirela Sedić (msedic@biotech.uniri.hr), 9. Lip. 2016. u 11:35 sati



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