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Pregled bibliografske jedinice broj: 82293

Časopis

Autori: Pavelić, Krešimir; Buković, Damir; Pavelić, Jasminka
Naslov: The role of insulin-like growth factor 2 and its receptors in human tumors
Izvornik: Molecular Medicine (1076-1551) 8 (2002); 881-780
Vrsta rada: članak
Ključne riječi: IGF2; IGF1 and 2 receptor; tumor
Sažetak:
Insulin-like growth factor 2 (IGF2) is important for normal development and growth of an organism. In humans it is encoded by 11p15.5 paternally expressed-imprinted gene. It binds at least two different types of receptors: IGF type 1 (IGF1R) and IGF1/mannose 6-phosphate receptors (IGF2R/M6P). Ligand binding to IGF1R provokes mitogenic and antiapoptotic effects. IGF2R/M6P has tumor suppressor function - it mediates IGF 2 degradation. When the IGF2 gene/protein is overexpressed, mostly as a consequence of loss of heterozygosity resulting in paternal allele duplication (LOH) or by loss of imprinting (LOI), it is involved in the development and progression of many tumors and overgrowth syndromes by autocrine or paracrine mechanisms.
Projekt / tema: 00981104, 00981103, 0098093, 0098092
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: The role of insulin-like growth factor 2 and its receptors in human tumors



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