Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

The role of insulin-like growth factor 2 and its receptors in human tumors (CROSBI ID 94674)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavelić, Krešimir ; Buković, Damir ; Pavelić, Jasminka The role of insulin-like growth factor 2 and its receptors in human tumors // Molecular medicine, 8 (2002), 881-780-x

Podaci o odgovornosti

Pavelić, Krešimir ; Buković, Damir ; Pavelić, Jasminka

engleski

The role of insulin-like growth factor 2 and its receptors in human tumors

Insulin-like growth factor 2 (IGF2) is important for normal development and growth of an organism. In humans it is encoded by 11p15.5 paternally expressed-imprinted gene. It binds at least two different types of receptors: IGF type 1 (IGF1R) and IGF1/mannose 6-phosphate receptors (IGF2R/M6P). Ligand binding to IGF1R provokes mitogenic and antiapoptotic effects. IGF2R/M6P has tumor suppressor function - it mediates IGF 2 degradation. When the IGF2 gene/protein is overexpressed, mostly as a consequence of loss of heterozygosity resulting in paternal allele duplication (LOH) or by loss of imprinting (LOI), it is involved in the development and progression of many tumors and overgrowth syndromes by autocrine or paracrine mechanisms.

IGF2; IGF1 and 2 receptor; tumor

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

8

2002.

881-780-x

objavljeno

1076-1551

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost