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Pregled bibliografske jedinice broj: 823333

Časopis

Autori: Šarolić, Antonio; Živković, Zlatko; Reilly, Patrick J
Naslov: Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model
Izvornik: Physics in Medicine & Biology (0031-9155) 61 (2016), 12; 4364-4375
Vrsta rada: članak
Ključne riječi: electrostimulation ; strength-duration (SD) curve ; excitation threshold frequency dependency ; SENN model ; single-axon measurement setup ; Lumbricus terrestris ; myelinated and unmyelinated fibers
Sažetak:
The electrostimulation excitation threshold of a nerve depends on temporal and frequency parameters of the stimulus. These dependences were investigated in terms of: (1) strength-duration (SD) curve for a single monophasic rectangular pulse, and (2) frequency dependence of the excitation threshold for a continuous sinusoidal current. Experiments were performed on the single-axon measurement setup based on Lumbricus terrestris having unmyelinated nerve fibers. The simulations were performed using the wellestablished SENN model for a myelinated nerve. Although the unmyelinated experimental model differs from the myelinated simulation model, both refer to a single axon. Thus we hypothesized that the dependence on temporal and frequency parameters should be very similar. The comparison was made possible by normalizing each set of results to the SD time constant and the rheobase current of each model, yielding the curves that show the temporal and frequency dependencies regardless of the model differences. The results reasonably agree, suggesting that this experimental setup and method of comparison with SENN model can be used for further studies of waveform effect on nerve excitability, including unmyelinated neurons.
Projekt / tema: 023-0000000-3273
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Fizika,Elektrotehnika,Temeljne medicinske znanosti
URL Internet adrese: http://iopscience.iop.org/article/10.1088/0031-9155/61/12/4364
Broj citata:
Altmetric:
DOI: 10.1088/0031-9155/61/12/4364
URL cjelovitog teksta:
Google Scholar: Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model
Upisao u CROSBI: Antonio Šarolić (Antonio.Sarolic@fesb.hr), 24. Lip. 2016. u 18:07 sati



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