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Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model (CROSBI ID 229740)

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Šarolić, Antonio ; Živković, Zlatko ; Reilly, Patrick J Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model // Physics in medicine and biology, 61 (2016), 12; 4364-4375. doi: 10.1088/0031-9155/61/12/4364

Podaci o odgovornosti

Šarolić, Antonio ; Živković, Zlatko ; Reilly, Patrick J

engleski

Measurement and simulation of unmyelinated nerve electrostimulation: Lumbricus terrestris experiment and numerical model

The electrostimulation excitation threshold of a nerve depends on temporal and frequency parameters of the stimulus. These dependences were investigated in terms of: (1) strength-duration (SD) curve for a single monophasic rectangular pulse, and (2) frequency dependence of the excitation threshold for a continuous sinusoidal current. Experiments were performed on the single-axon measurement setup based on Lumbricus terrestris having unmyelinated nerve fibers. The simulations were performed using the wellestablished SENN model for a myelinated nerve. Although the unmyelinated experimental model differs from the myelinated simulation model, both refer to a single axon. Thus we hypothesized that the dependence on temporal and frequency parameters should be very similar. The comparison was made possible by normalizing each set of results to the SD time constant and the rheobase current of each model, yielding the curves that show the temporal and frequency dependencies regardless of the model differences. The results reasonably agree, suggesting that this experimental setup and method of comparison with SENN model can be used for further studies of waveform effect on nerve excitability, including unmyelinated neurons.

electrostimulation ; strength-duration (SD) curve ; excitation threshold frequency dependency ; SENN model ; single-axon measurement setup ; Lumbricus terrestris ; myelinated and unmyelinated fibers

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Podaci o izdanju

61 (12)

2016.

4364-4375

objavljeno

0031-9155

10.1088/0031-9155/61/12/4364

Povezanost rada

Fizika, Elektrotehnika, Temeljne medicinske znanosti

Poveznice
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