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Pregled bibliografske jedinice broj: 825352

Časopis

Autori: Tariba, Blanka; Živković, Tanja; Filipović Marijić, Vlatka; Erk, Marijana; Gamulin, Marija; Pizent, Alica
Naslov: Does the Serum Metallothionein level reflect the stage of testicular germ cell tumor?
( Does the Serum Metallothionein level reflect the stage of testicular germ cell tumor? )
Izvornik: Archives of medical research (0188-4409) 47 (2016); 232-235
Vrsta rada: prethodno priopćenje
Ključne riječi: Metallothionein ; Non-seminoma ; Seminoma ; serum marker ; testicular germ cell tumor
( Metallothionein ; Non-seminoma ; Seminoma ; serum marker ; testicular germ cell tumor )
Sažetak:
Increased levels of metallothionein (MT) have recently been found in the blood serum of men with newly diagnosed testicular germ cell tumors (TGCT). In light of previously published results, the aim of this study was to investigate the difference in serum MT levels among patients with different stages of TGCT and compare MT with commonly used markers (α- fetoprotein, β-human chorionic gonadotropin and lactate dehydrogenase). The concentration of total MT was determined in the serum of 25 men with TGCT (seminoma or non-seminoma) by differential pulse voltammetry. Serum samples were obtained prior to chemotherapy, after two cycles of chemotherapy and 1 year after chemotherapy. A statistically significant difference in MT levels in patients with different stages of TGCT was observed in the serum of patients with non-seminoma obtained before chemotherapy. Although not significant, an increase in serum MT levels commensurate with the disease stage increase was also observed in patients with seminomatous TGCT. The results indicate that, in combination with the existing markers, MT could be useful for the identification of the histological type of tumor and stage of the disease before biopsy diagnosis.
Projekt / tema: 022-0222411-2408
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0188440916300194
http://dx.doi.org/10.1016/j.arcmed.2016.05.005
Broj citata:
Altmetric:
DOI: 10.1016/j.arcmed.2016.05.005
URL cjelovitog teksta:
Google Scholar: Does the Serum Metallothionein level reflect the stage of testicular germ cell tumor?
Upisao u CROSBI: Blanka Tariba (btariba@imi.hr), 5. Srp. 2016. u 10:37 sati



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