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Pregled bibliografske jedinice broj: 827890

Časopis

Autori: Jaillon, Sébastien; Moalli, Federica; Ragnarsdottir, Bryndis; Bonavita, Eduardo; Puthia, Manoj; Riva, Federica; Barbati, Elisa; Nebuloni, Manuela; Cvetko Krajinovic, Lidija; Markotic, Alemka; Valentino, Sonia; Doni, Andrea; Tartari, Silvia; Graziani, Giorgio; Montanelli, Alessandro; Delneste, Yves; Svanborg, Catharina; Garlanda, Cecilia; Mantovani, Alberto
Naslov: The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection
( The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection )
Izvornik: Immunity (1074-7613) 40 (2014), 4; 621-632
Vrsta rada: članak
Ključne riječi: PTX3 ; innate immunity ; uroinfections
( PTX3 ; innate immunity ; uroinfections )
Sažetak:
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognitionmolecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88- dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In cohorts of UTI-prone patients, PTX3 gene polymorphisms correlated with susceptibility to acute pyelonephritis and cystitis. These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1074761314001137
http://dx.doi.org/10.1016/j.immuni.2014.02.015
Broj citata:
Altmetric:
DOI: 10.1016/j.immuni.2014.02.015
URL cjelovitog teksta:
Google Scholar: The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection
Upisao u CROSBI: Lidija Cvetko (lcvetko@bfm.hr), 18. Srp. 2016. u 15:47 sati



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