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Pregled bibliografske jedinice broj: 828332

Časopis

Autori: Zorić, Nataša; Kopjar, Nevenka; Kraljić, Klara; Oršolić, Nada; Tomić, Siniša; Kosalec, Ivan
Naslov: Olive leaf extract activity against Candida albicans and C. dubliniensis – the in vitro viability study
( Olive leaf extract activity against Candida albicans and C. dubliniensis – the in vitro viability study )
Izvornik: Acta pharmaceutica (1330-0075) 66 (2016), 3; 411-431
Vrsta rada: članak
Ključne riječi: anifungal activity ; Candida albicans ; Candida dubliniensis ; olive leaf extract
( olive leaf extract activity against Candida albicans and C. dubliniensis – the in vitro viability study )
Sažetak:
Olive leaf extract is characterized by a high content of polyphenols (oleuropein, hydroxytyrosol and their derivatives), which is associated with its therapeutic properties. The objective of the present research was to evaluate the antifungal activity of olive leaf aqueous extract against Candida albicans ATCC 10231 and C. dubliniensis CBS 7987 strains. Minimum inhibitory concentration (MIC) of the extract was determined by several in vitro assays. The extract showed a concentration dependent effects on the viability of C. albicans with MIC value of 46.875 mg mL–1 and C. dubliniensis with MIC value 62.5 mg mL–1. Most sensitive methods for testing the antifungal effect of the extract were the trypan blue exclusion method and fluorescent dye exclusion method while MIC could not be determined by the method according to the EUCAST recommendation suggesting that herbal preparations contain compounds that may interfere with this susceptibility testing. The fluorescent dye exclusion method was also used for the assessment of morphological changes in the nuclei of the treated cells. According to the obtained results, olive leaf extract is less effective against the tested strains than hydroxytyrosol, an olive plant constituent tested in our previous study.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
URL Internet adrese: http://hrcak.srce.hr/file/231215
Broj citata:
Altmetric:
DOI: 10.1515/acph-2016-0033
URL cjelovitog teksta:
Google Scholar: Olive leaf extract activity against Candida albicans and C. dubliniensis – the in vitro viability study
Upisao u CROSBI: Ivan Kosalec (ikosalec@pharma.hr), 21. Srp. 2016. u 13:37 sati



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