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Pregled bibliografske jedinice broj: 829280

Časopis

Autori: Pospišil, Tihomir; Žinić, Mladen; Frkanec, Leo
Naslov: TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS
( TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS )
Izvornik: Czech Chemical Society Symposium Series (2336-7202) 14 (2016), 3; 126-126a
Vrsta rada: Sažetak s kongresa
Ključne riječi: Aβ-amyloid aggregates ; Supramolecular self assembly ; Low molecular weight peptidic gelators ; Binding of histological dyes
( Aβ-amyloid aggregates ; Supramolecular self assembly ; Low molecular weight peptidic gelators ; Binding of histological dyes )
Sažetak:
Series of tripeptide FFA derivatives was synthesized and tested for gelation of water and organic solvents. Only Ac-FFA-NH2 tripeptide exhibited gelation of water by self- assembly under physiological conditions. TEM of the Ac- FFA-NH2 hydrogel and the methanol/water gel showed the presence of straight fibers with relatively uniform diameters of around 50 nm. FTIR and NMR investigation pointed toward the cross-β structure type of hydrogen bonding of the tripeptide in the gel aggregates. Conjugated dyes (Thioflavin T and Congo Red) are commonly used to stain the plaques in histopathological studies3. Fluorescence titration of Ac-FFA-NH2 aqueous solution bellow its minimal gelation concentration with Thioflavin T (ThT) showed increase of ThT emission with increased tripeptide concentration and formation of the 1 : 1 complex with significant association constant.
Projekt / tema: HRZZ-IP-1-2013-7387, 098-0982904-2912
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://www.ccsss.cz/index.php/ccsss/issue/view/3
URL cjelovitog teksta:
Google Scholar: TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS
Upisao u CROSBI: Leo Frkanec (Leo.Frkanec@irb.hr), 6. Kol. 2016. u 19:04 sati



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