crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 829281

Zbornik radova

Autori: Pospišil, Tihomir; Žinić, Mladen; Frkanec, Leo
Naslov: Tripeptide hydrogelator (Ac-FFA-NH2) as a model of binding site Aβ-protein ; comparative binding studies with Thioflavin-T and other Aβ- binders
Izvornik: SysChem 2016, Abstract Book / Radmila Řápková, Pavel Drašar (ur.). - Prag : Chemicke listy, Association of Czech Chemical Societies, , 2016. 126-126a.
Skup: SysChem 2016, CMST COST Action CM1304 Emergence and Evolution of Complex Chemical Systems
Mjesto i datum: Valtice Chateau, Čehoslovačka, 8.-12. 05. 2016.
Ključne riječi: Aβ-amyloid aggregates; Supramolecular self assembly; Low molecular weight peptidic gelators; Binding of histological dyes
Sažetak:
Series of tripeptide FFA derivatives was synthesized and tested for gelation of water and organic solvents. Only Ac-FFA-NH2 tripeptide exhibited gelation of water by self- assembly under physiological conditions. TEM of the Ac- FFA-NH2 hydrogel and the methanol/water gel showed the presence of straight fibers with relatively uniform diameters of around 50 nm. FTIR and NMR investigation pointed toward the cross-β structure type of hydrogen bonding of the tripeptide in the gel aggregates. Conjugated dyes (Thioflavin T and Congo Red) are commonly used to stain the plaques in histopathological studies3. Fluorescence titration of Ac-FFA-NH2 aqueous solution bellow its minimal gelation concentration with Thioflavin T (ThT) showed increase of ThT emission with increased tripeptide concentration and formation of the 1 : 1 complex with significant association constant.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: HRZZ-IP-2013-11-7387, 098-0982904-2912
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: Leo Frkanec (Leo.Frkanec@irb.hr), 6. Kol. 2016. u 19:29 sati



Verzija za printanje   za tiskati


upomoc
foot_4