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Pregled bibliografske jedinice broj: 830562

Časopis

Autori: Štimac, Adela; Trmčić Cvitaš, Jelena; Frkanec, Leo; Vugrek, Oliver; Frkanec, Ruža
Naslov: Design and syntheses of mono and multivalent mannosyl-lipoconjugates for targeted liposomal drug delivery
( Design and syntheses of mono and multivalent mannosyl-lipoconjugates for targeted liposomal drug delivery )
Izvornik: International journal of pharmaceutics (0378-5173) 511 (2016), 1; 44-56
Vrsta rada: članak
Ključne riječi: Targeted drug delivery ; Liposomes ; Glycolipids ; Mannose Receptor
( Targeted drug delivery ; Liposomes ; Glycolipids ; mannose Receptor )
Sažetak:
Multivalent mannosyl-lipoconjugates may be of interest for glycosylation of liposomes and targeted drug delivery because the mannose specifically binds to C-type lectin receptors on the particular cells. In this paper syntheses of two types of novel O-mannosides are presented. Conjugates 1 and 2 with a COOH- and NH2-functionalized spacer and the connection to a lysine and FmocNH-PEG-COOH, are described. The coupling reactions of prepared intermediates 6 and 4 with a PEGylated-DSPE or palmitic acid, respectively, are presented. Compounds 5, mono-, 8, di- and 12, tetravalent mannosyl-lipoconjugates, were synthesized. The synthesized compounds were incorporated into liposomes and liposomal preparations featuring exposed mannose units were characterized. Carbohydrate liposomal quartz crystal microbalance based assay has been established for studying carbohydrate–lectin binding. It was demonstrated that liposomes with incorporated mannosyl-lipoconjugates were effectively recognized by Con A and have great potential to be used for targeted liposomal drug delivery systems.
Projekt / tema: HRZZ-IP-2013-11-7387
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/journal/03785173
Broj citata:
Altmetric:
DOI: 10.1016/j.ijpharm.2016.06.123
URL cjelovitog teksta:
Google Scholar: Design and syntheses of mono and multivalent mannosyl-lipoconjugates for targeted liposomal drug delivery
Upisao u CROSBI: Ruža Frkanec (rfrkanec@unizg.hr), 29. Kol. 2016. u 14:29 sati



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