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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 830769

Časopis

Autori: Mihalj, Martina; Tadzic, Refmir; Vcev, Aleksandar; Rucevic, Silvija; Drenjancevic, Ines
Naslov: Blood pressure reduction is associated with the changes in oxidative stress and endothelial activation in hypertension, regardless of antihypertensive therapy
( Blood pressure reduction is associated with the changes in oxidative stress and endothelial activation in hypertension, regardless of antihypertensive therapy )
Izvornik: Kidney & blood pressure research (1420-4096) 41 (2016); 721-735
Vrsta rada: članak
Ključne riječi: 8-iso-prostaglandin F2-alpha ; hypertension ; AT1 receptor antagonists ; calcium channel blockers ; cell adhesion molecules
( 8-iso-prostaglandin F2-alpha ; hypertension ; AT1 receptor antagonists ; calcium channel blockers ; cell adhesion molecules )
Sažetak:
BACKGROUND: Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodium dismutase activity. AIMS: This study aimed to investigate the effects of antihypertensive therapy and also vitamin C/E supplementation on BP, oxidative stress and endothelial activation in patients with essential hypertension. METHODS: Newly discovered patients received ARB/olmesartan or the Ca2+-channel blocker (CCB)/amlodipine, and additionally vitamin C/E or placebo throughout weeks 9-16. ELISA was used to determine 8-iso-prostaglendin F2-alpha (8iPGF2α) and endothelial activation markers. RESULTS: In both groups BP was normalized during first 8 weeks of therapy. Vitamins C/E had no additional BP-lowering effect. The vitamins C/E supplementation was not effective in reducing absolute values of 8iPGF2α ; however ; the magnitude of 8iPGF2α reduction was significantly greater in patients taking vitamins C/E in the CCB group. Although plasma 8iPGF2α positively correlated to BP, a significant decrease occurred during an additional 8 weeks of treatment. There were no changes in endothelial activation markers related to the specific action of ARB or CCB. CONCLUSIONS: Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.karger.com/Article/FullText/450562
Broj citata:
Altmetric:
DOI: 10.1159/000450562
URL cjelovitog teksta:
Google Scholar: Blood pressure reduction is associated with the changes in oxidative stress and endothelial activation in hypertension, regardless of antihypertensive therapy
Upisao u CROSBI: Ines Drenjančević (ines.drenjancevic@mefos.hr), 31. Kol. 2016. u 15:32 sati



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