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Pregled bibliografske jedinice broj: 839296

Časopis

Autori: Levanat, Sonja; Sabol, Maja; Musani, Vesna; Ozretić, Petar; Trnski, Diana
Naslov: Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors
( Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors )
Izvornik: Current pharmaceutical design (1381-6128) 23 (2017), 1; 73-94
Vrsta rada: članak
Ključne riječi: Hedgehog signaling ; ovarian tumors ; cyclopamine ; miRNA ; methylation ; mutation ; therapy
( Hedgehog signaling ; ovarian tumors ; cyclopamine ; miRNA ; methylation ; mutation ; therapy )
Sažetak:
Hedgehog signaling pathway is a developmental pathway mostly inactive in adult tissues, with the exception of stem cells. It is often found upregulated in various tumors, and associated with cancer stem cell maintenance. Mutations in pathway components lead to a series of developmental malformations and syndromes. Aberrant activation of the pathway can be caused by mutations, non-canonical transcriptional regulation, or epigenetic changes. This makes this pathway an interesting target in cancer therapy, especially when combined with therapies targeting other signaling pathways. Combination therapy can be used to bypass resistance or to target cancer stem cells in a more efficient way. This review focuses on different aspects of Hedgehog activation in tumors, with special emphasis on ovarian tumors and their treatment.
Projekt / tema: 098-0982464-2461
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.2174/1381612822666161006154705
http://benthamscience.com/journals/current-pharmaceutical-design/article/146138/
Broj citata:
Altmetric:
DOI: 10.2174/1381612822666161006154705
URL cjelovitog teksta:
Google Scholar: Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors
Upisao u CROSBI: Petar Ozretić (Petar.Ozretic@irb.hr), 17. Lis. 2016. u 17:51 sati



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