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Pregled bibliografske jedinice broj: 852281

Časopis

Autori: Zorić, Nataša; Kopjar, Nevenka; Bobnjarić, Ivan; Horvat, Igor; Tomić, Siniša; Kosalec, Ivan
Naslov: Antifungal Activity of Oleuropein against Candida albicans—The In Vitro Study
( Antifungal Activity of Oleuropein against Candida albicans—The In Vitro Study )
Izvornik: Molecules (1420-3049) 21 (2016), 12; 1631-1-1631-9
Vrsta rada: članak
Ključne riječi: oleuropein ; antifungal activity ; Candida albicans ; virulence factors
( oleuropein ; antifungal activity ; Candida albicans ; virulence factors )
Sažetak:
In the present study we investigated activity of oleuropein, a complex phenol present in large quantities in olive tree products, against opportunistic fungal pathogen Candida albicans. Oleuropein was found to have in vitro antifungal activity with a minimal inhibitory concentration (MIC) value of 12.5 mg·mL−1. Morphological changes in the nuclei after staining with fluorescent DNA-binding dyes revealed that apoptosis was a primary mode of cell death in the analyzed samples treated with subinhibitory concentrations of oleuropein. Our results suggest that this antifungal agent targets virulence factors essential for establishment of the fungal infection. We noticed that oleuropein modulates morphogenetic conversion and inhibits filamentation of C. albicans. The hydrophobicity assay showed that oleuropein in sub-MIC values has significantly decreased, in both aerobic and anaerobic conditions, the cellular surface hydrophobicity (CSH) of C. albicans, a factor associated with adhesion to epithelial cells. It was also demonstrated that the tested compound inhibits the activity of SAPs, cellular enzymes secreted by C. albicans, which are reported to be related to the pathogenicity of the fungi. Additionally, we detected that oleuropein causes a reduction in total sterol conten
Izvorni jezik: eng
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bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
URL Internet adrese: http://www.mdpi.com/1420-3049/21/12/1631/htm
Broj citata:
Altmetric:
DOI: 10.3390/molecules21121631
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Antifungal Activity of Oleuropein against Candida albicans—The In Vitro Study
Upisao u CROSBI: Ivan Kosalec (ikosalec@pharma.hr), 26. Pro. 2016. u 16:26 sati
Napomene:
Rad je dio problematike doktorsko grada Nataše Zorić pod mentorstvom Ivana Kosalca i Siniše Tomića



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