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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 857344

Časopis

Autori: Pagani, L.; Lawson, D.J.; Jagoda, E.; ...; Škaro, Vedrana; Mulahasanović, L.; Primorac, Dragan; ...; Marjanović, Damir; ...; Metspalu, M.
Naslov: Genomic analyses inform on migration events during the peopling of Eurasia
Izvornik: Nature (0028-0836) 538 (2016), 7634; 238-242
Vrsta rada: članak
Ključne riječi: genome, peopling, Eurasia
Sažetak:
High-coverage whole-genome sequence studies have so far focused on a limited number1 of geographically restricted populations2, 3, 4, 5, or been targeted at specific diseases, such as cancer6. Nevertheless, the availability of high- resolution genomic data has led to the development of new methodologies for inferring population history7, 8, 9 and refuelled the debate on the mutation rate in humans10. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record11, and admixture between AMHs and Neanderthals predating the main Eurasian expansion12, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75, 000 years ago.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL Internet adrese: http://www.nature.com/nature/journal/v538/n7624/full/nature19792.html
Broj citata:
Altmetric:
DOI: 10.1038/nature19792
URL cjelovitog teksta:
Google Scholar: Genomic analyses inform on migration events during the peopling of Eurasia
Upisao u CROSBI: Ana Klopotan (ana.klopotan@inantro.hr), 23. Sij. 2017. u 10:25 sati



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