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Pregled bibliografske jedinice broj: 86059

Zbornik radova

Autori: Džolić, Zoran; Kristafor, Vedran; Cetina, Mario; Nagl, Ante; Hergold-Brundić, Antonija; Mrvoš-Sermek, Draginja; Slade, Neda; Pavelić, Krešimir; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Naslov: The Novel Spacered Cyclopropyl Nucleoside Analogues : Synthesis, Structural Studies And Biological Evaluation Of The Purine Supstituted 1-Aminocyclopropane-1-Carboxylic Acids And 1-Amino-1-Hydroxymethylcyclopropanes
Izvornik: XV International Round Table "Nucleosides, Nucleotides & Nucleic Acids" / De Clercq, Erik, Herdewijn, Piet (ur.). - Leuven :
Skup: XV International Round Table "Nucleosides, Nucleotides & Nucleic Acids"
Mjesto i datum: Leuven, Belgija, 10-14.09.2002.
Ključne riječi: purine derivatives
Sažetak:
The novel purine derivatives of 1-aminocyclopropane-1-carboxylic acid (7, 8) and 1-amino-1-hydroxymethylcyclopropane (11, 12) containing methylene spacer between the base and the cyclopropane ring were prepared by multistep synthetic route involving alkylation of appropriately substituted purine with specifically protected methyl 1-[N-(tert-Boc)amino]-2-(O-Ts-hydroxymethyl)cyclopropane-1-carboxylate as a key reaction. Z-configuration of the novel compounds was determined by one and two dimensional 1H and 13C NMR techniques and X-ray structure analyses. The novel compounds were evaluated on cytostatic and antiviral activities on several cell lines. The compound 11 exhibited a more pronounced inhibitory activity against the proliferation of cervical carcinoma (HeLa) and human fibroblast (WI-38) cells than other types of tumor cell lines. None of the compounds showed inhibitory activities against CMV, VZV and several other viruses.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 0125003, 0098092
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti



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