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izvor podataka: crosbi

Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia (CROSBI ID 237047)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mladinov, Mihovil ; Sedmak, Goran ; Fuller, Heidi R. ; Babić Leko, Mirjana ; Mayer, Davor ; Kirincich, Jason ; Štajduhar, Andrija ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia // Translational Neuroscience, 7 (2016), 1; 139-150. doi: 10.1515/tnsci-2016-0021

Podaci o odgovornosti

Mladinov, Mihovil ; Sedmak, Goran ; Fuller, Heidi R. ; Babić Leko, Mirjana ; Mayer, Davor ; Kirincich, Jason ; Štajduhar, Andrija ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran

engleski

Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia

Schizophrenia is a complex polygenic disorder of unknown etiology. Over 3, 000 candidate genes associated with schizophrenia have been reported, most of which being mentioned only once. Alterations in cognitive processing - working memory, metacognition and mentalization - represent a core feature of schizophrenia, which indicates the involvement of the prefrontal cortex in the pathophysiology of this disorder. Hence we compared the gene expression in postmortem tissue from the left and right dorsolateral prefrontal cortex (DLPFC, Brodmann's area 46), and the medial part of the orbitofrontal cortex (MOFC, Brodmann's area 11/12), in six patients with schizophrenia and six control brains. Although in the past decade several studies performed transcriptome profiling in schizophrenia, this is the first study to investigate both hemispheres, providing new knowledge about possible brain asymmetry at the level of gene expression and its relation to schizophrenia. We found that in the left hemisphere, twelve genes from the DLPFC and eight genes from the MOFC were differentially expressed in patients with schizophrenia compared to controls. In the right hemisphere there was only one gene differentially expressed in the MOFC. We reproduce the involvement of previously reported genes TARDBP and HNRNPC in the pathogenesis of schizophrenia, and report seven novel genes: SART1, KAT7, C1D, NPM1, EVI2A, XGY2, and TTTY15. As the differentially expressed genes only partially overlap with previous studies that analyzed other brain regions, our findings indicate the importance of considering prefrontal cortical regions, especially those in the left hemisphere, for obtaining disease-relevant insights.

brain asymmetry ; dorsolateral prefrontal cortex ; gene expression ; orbitofrontal cortex ; schizophrenia ; transcriptomics

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Podaci o izdanju

7 (1)

2016.

139-150

objavljeno

2081-3856

2081-6936

10.1515/tnsci-2016-0021

Povezanost rada

Temeljne medicinske znanosti

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