Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 865259

Časopis

Autori: Klobučar, Marko; Visentin, Sarah; Jakovčević, Antonija; Bilić, Mario; Kovač-Bilić, Lana; Đanić, Davorin; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Naslov: Expression of polysialic acid in primary laryngeal squamous cell carcinoma
( Expression of polysialic acid in primary laryngeal squamous cell carcinoma )
Izvornik: Life sciences (0024-3205) 173 (2017); 73-79
Vrsta rada: članak
Ključne riječi: FGFR-MAPK/Erk1/2signaling ; Laryngeal squamous cell carcinoma ; Metastases ; Polysialic acid ; Polysialyltransferase
( FGFR-MAPK/Erk1/2signaling ; Laryngeal squamous cell carcinoma ; Metastases ; Polysialic acid ; Polysialyltransferase )
Sažetak:
AIMS: Expression of polySia is associated with metastatic dissemination and progression of various malignant diseases. In particular, it may contribute to tumorigenesis by a negative modulatory effect on cellular signaling cascades responsible for cellular migration, differentiation and proliferation. In this study, we investigated the expression of polySia in primary metastatic and non-metastatic laryngeal squamous cell carcinoma (LSCC) tumor tissues and its potential impact on the LSCC progression. MAIN METHODS: The expression of polySia in metastatic and non- metastatic primary laryngeal squamous cell carcinoma (LSCC) tumor biopsy specimens was investigated by immunohistochemistry, while the expression of polysialyltransferase IV (ST8SiaIV) (), fibroblast growth factor receptor 1 (FGFR1), extracellular signal regulated kinases 1 and 2 (Erk 1/2) and c-Raf was tested in metastatic and non-metastatic primary tumor tissues (including the corresponding non-tumor control tissues) by Western blot analysis. KEY FINDINGS: The expression of polySia was detected in LSCC biopsies specimens with generally stronger immunoreactivity in non-metastatic tumor LSCC sections and in histologically undifferentiated tumors. Also, increased polySia expression was observed in adjacent histologically unaltered laryngeal tumor-associated tissue of the metastatic sections. In addition, we provide an evidence of increased polysialyltransferase IV (ST8SiaIV) expression, involved in polySia synthesis in both metastatic and non-metastatic primary tumors which is accompanied by decreased levels of FGFR1, Erk 1/2 and c-Raf. SIGNIFICANCE: We present for the first time the evidence for the polySia expression in LSCC biopsies specimens which suggests its potential impact on initial steps of LSCC malignant transformation.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0024320517300395
http://dx.doi.org/10.1016/j.lfs.2017.02.002
Broj citata:
Altmetric:
DOI: 10.1016/j.lfs.2017.02.002
URL cjelovitog teksta:
Google Scholar: Expression of polysialic acid in primary laryngeal squamous cell carcinoma
Upisao u CROSBI: Snježana Prelević (snjezana.prelevic@mefos.hr), 9. Ožu. 2017. u 12:56 sati