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Pregled bibliografske jedinice broj: 869473

Časopis

Autori: Knežević Teofilović, Natalija; Bihi, Majjoub; Radić Stojković, Marijana; Tumir, Lidija; Ester, Katja; Kralj, Marijeta; Majhen, Dragomira; Oršolić, Nada; Lepur, Adriana; Vrbanec, Damir; Markotić, Alemka; Dembić, Zlatko; Weber, Alexander N.R; Piantanida, Ivo; Vugrek, Oliver; Diken, Mustafa; Knežević, Jelena
Naslov: 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro
( 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro )
Izvornik: Bioorganic & medicinal chemistry letters (0960-894X) 27 (2017), 7; 1530-1537
Vrsta rada: članak
Ključne riječi: phenantridines, TLR, PBMCs, cytokines, immunomodulation
( fenantridini, TLR, PBMC, citokini, imunomodulacija )
Sažetak:
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).
Projekt / tema: FP7-REGPOT-2012-2013-1
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://doi.org/10.1016/j.bmcl.2017.02.048
http://www.sciencedirect.com/science/article/pii/S0960894X17301816
Broj citata:
Altmetric:
DOI: 10.1016/j.bmcl.2017.02.048
URL cjelovitog teksta:
Google Scholar: 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro
Upisao u CROSBI: Dragomira Majhen (Dragomira.Majhen@irb.hr), 7. Tra. 2017. u 12:46 sati



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