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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 877436

Časopis

Autori: Zorić, Nataša; Kosalec, Ivan; Tomić, Siniša; Bobnjarić, Ivan; Jug, Mario; Vlainić, Toni; Vlainić, Josipa
Naslov: Membrane of Candida albicans as a target of berberine
( Membrane of Candida albicans as a target of berberine )
Izvornik: BMC Complementary and Alternative Medicine (1472-6882) 17 (2017), 1; 268-1-268-
Vrsta rada: članak
Ključne riječi: Berberine, Candida albicans, Antifungal, Membrane
( Berberine, Candida albicans, Antifungal, Membrane )
Sažetak:
We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species. The effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed. Minimal inhibitory concentration (MIC) of berberine against C. albicans was 17.75 μg/mL. Cytotoxic effect of berberine was concentration dependent, and in sub-MIC concentrations inhibit morphological transition of C. albicans cells to its filamentous form. Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage). Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane. Moreover, ROS levels were also increased following berberine treatment indicating further the possibility of membrane damage. Based on the obtained results it seems that berberine achieves its anti-Candida activity by affecting the cell membrane.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Farmacija
Puni text rada: 877436.Zoric_et_al-2017-BMC_Complementary_and_Alternative_Medicine.pdf (tekst priložen 26. Svi. 2017. u 10:31 sati)
URL Internet adrese: https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1773-5
Broj citata:
Altmetric:
DOI: 10.1186/s12906-017-1773-5
URL cjelovitog teksta:
Google Scholar: Membrane of Candida albicans as a target of berberine
Upisao u CROSBI: Ivan Kosalec (ikosalec@pharma.hr), 26. Svi. 2017. u 10:31 sati
Napomene:
Rad je proizašao iz doktorske disertacije Nataše Zorić (mentori prof. Kosalec i prof. Tomić). Rad je također u ko-autorstvu sa studentom (I. Bobnjarić).



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