Hrvatska znanstvena bibliografija (CROSBI)

Pregled bibliografske jedinice broj: 880109


Autori: Milković, Lidija; Žarković, Neven; Saso, Luciano.
Naslov: Controversy about pharmacological modulation of Nrf2 for cancer therapy
Izvornik: Redox Biology (2213-2317) 12 (2017); 727-732
Vrsta rada: pregledni rad
Ključne riječi: Cancer ; Nrf2 ; Oxidative stress ; Cancer therapy ; Growth regulation ; 4-hydroxynonenal
Conventional anticancer therapies such as radiotherapy and chemotherapies are associated with oxidative stress generating reactive oxygen species (ROS) and reactive aldehydes like 4-hydroxynonenal in cancer cells that govern them to die. The main mechanism activated due to exposure of the cell to these reactive species is the Nrf2-Keap1 pathway. Although Nrf2 was firstly perceived as a tumor suppressor that inhibits tumor initiation and cancer metastasis, more recent data reveal its role also as a pro-oncogenic factor. Discovery of the upregulation of Nrf2 in different types of cancer supports such undesirable pathophysiological roles of Nrf2. The upregulation of Nrf2 leads to activation of cytoprotective genes thus helping malignant cells to withstand high levels of ROS and to avoid apoptosis, eventually becoming resistant to conventional anticancer therapy. Therefore, new treatment strategies are needed for eradication of cancer and in this review, we will explore two opposing approaches for modulation of Nrf2 in cancer treatments.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Broj citata:
DOI: 10.1016/j.redox.2017.04.013
URL cjelovitog teksta:
Google Scholar: Controversy about pharmacological modulation of Nrf2 for cancer therapy
Upisao u CROSBI: Lidija Milković (, 9. Lip. 2017. u 11:52 sati