Hrvatska znanstvena bibliografija (CROSBI)

Pregled bibliografske jedinice broj: 880113


Autori: Čipak Gašparović, Ana; Milković, Lidija; Borović Šunjić, Suzana; Žarković, Neven
Naslov: Cancer growth regulation by 4-hydroxynonenal
Izvornik: Free radical biology & medicine (0891-5849) 111 (2017); 226-234
Vrsta rada: članak
Ključne riječi: 4-Hydroxynonenal (HNE) ; Lipid peroxidation ; Oxidative stress ; Cancer ; Carcinogenesis ; Cancer therapy ; Pathophysiology ; Growth regulation ; Signaling
While reactive oxygen species (ROS) gain their carcinogenic effects by DNA mutations, if generated in the vicinity of genome, lipid peroxidation products, notably 4-hydroxynonenal (HNE), have much more complex modes of activities. Namely, while ROS are short living and have short efficiency distance range (in nm or µm) HNE has strong binding affinity for proteins, thus forming relatively stable adducts. Hence, HNE can diffuse from the site or origin changing structure and function of respective proteins. Consequently HNE can influence proliferation, differentiation and apoptosis of cancer cells on one hand, while on the other it can affect genome functionality, too. Although HNE is considered to be important factor of carcinogenesis due to its ability to covalently bind to DNA, it might also be cytotoxic for cancer cells, as well as it can modulate their growth. In addition to direct cytotoxicity, HNE is also involved in activity mechanisms by which several cytostatic drugs and radiotherapy exhibit their anticancer effects. Complementary to that, the metabolic pathway for HNE detoxification through RLIP76, which is enhanced in cancer, may be a target for anti-cancer treatments. In addition, some cancer cells can undergo apoptosis or necrosis, if exposed to supraphysiological HNE levels in the cancer microenvironment, especially if challenged additionally by pro-oxidative cytostatics and/or inflammation. These findings could explain previously observed disappearance of HNE from invading cancer cells, which is associated with the increase of HNE in non-malignant cells close to invading cancer utilizing cardiolipin as the source of cancer-inhibiting HNE.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese:
Broj citata:
DOI: 10.1016/j.freeradbiomed.2017.01.030
URL cjelovitog teksta:
Google Scholar: Cancer growth regulation by 4-hydroxynonenal
Upisao u CROSBI: Lidija Milković (, 9. Lip. 2017. u 12:17 sati