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Pregled bibliografske jedinice broj: 880459

Časopis

Autori: Bruvere, Imanta; Bisenieks, Egils; Poikans, Janis; Uldrikis, Janis; Plotniece, Aiva; Pajuste, Karlis; Rucins, Martins; Vigante, Brigita; Kalme, Zenta; Gosteva, Marina; Domracheva, Ilona; Velena, Astrida; Vukovic, Tea; Milkovic, Lidija; Duburs, Gunars; Zarkovic, Neven.
Naslov: Dihydropyridine Derivatives as Cell Growth Modulators In Vitro
Izvornik: Oxidative Medicine and Cellular Longevity (1942-0900) 2017 (2017); 4069839-1-4069839-15
Vrsta rada: članak
Ključne riječi: dihydropyridine derivatives ; cell growth ; antiradical activity
Sažetak:
The effects of eleven 1, 4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) antioxidant diludine ; (2) derivatives with pyridinium moieties at position 4 of the 1, 4-DHP ring ; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1, 4-DHP ring. Diludine and DHPs of group 3 exerted antiradical activities, unlike compounds of group 2. However, novel DHPs had cell type and concentration dependent effects on 3H-thymidine incorporation, while diludine did not. Hence, IB-32 (group 2) suppressed the growth of HOS and HeLa, enhancing growth of L929 cells, while K-2-11 (group 3) enhanced growth of every cell line tested, even in the presence of doxorubicin. Therefore, growth regulating and antiradical activity principles of novel DHPs should be further studied to find if DHPs of group 2 could selectively suppress cancer growth and if those of group 3 promote wound healing.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: https://www.hindawi.com/journals/omcl/2017/4069839/
Broj citata:
Altmetric:
DOI: 10.1155/2017/4069839
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Dihydropyridine Derivatives as Cell Growth Modulators In Vitro
Upisao u CROSBI: Lidija Milković (Lidija.Milkovic@irb.hr), 12. Lip. 2017. u 08:15 sati



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