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Dihydropyridine Derivatives as Cell Growth Modulators In Vitro (CROSBI ID 240004)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bruvere, Imanta ; Bisenieks, Egils ; Poikans, Janis ; Uldrikis, Janis ; Plotniece, Aiva ; Pajuste, Karlis ; Rucins, Martins ; Vigante, Brigita ; Kalme, Zenta ; Gosteva, Marina et al. Dihydropyridine Derivatives as Cell Growth Modulators In Vitro // Oxidative medicine and cellular longevity, 2017 (2017), 4069839-1-4069839-15. doi: 10.1155/2017/4069839

Podaci o odgovornosti

Bruvere, Imanta ; Bisenieks, Egils ; Poikans, Janis ; Uldrikis, Janis ; Plotniece, Aiva ; Pajuste, Karlis ; Rucins, Martins ; Vigante, Brigita ; Kalme, Zenta ; Gosteva, Marina ; Domracheva, Ilona ; Velena, Astrida ; Vukovic, Tea ; Milkovic, Lidija ; Duburs, Gunars ; Zarkovic, Neven.

engleski

Dihydropyridine Derivatives as Cell Growth Modulators In Vitro

The effects of eleven 1, 4-dihydropyridine derivatives (DHPs) used alone or together with prooxidant anticancer drug doxorubicin were examined on two cancer (HOS, HeLa) and two nonmalignant cell lines (HMEC, L929). Their effects on the cell growth (3H-thymidine incorporation) were compared with their antiradical activities (DPPH assay), using well-known DHP antioxidant diludine as a reference. Thus, tested DHPs belong to three groups: (1) antioxidant diludine ; (2) derivatives with pyridinium moieties at position 4 of the 1, 4-DHP ring ; (3) DHPs containing cationic methylene onium (pyridinium, trialkylammonium) moieties at positions 2 and 6 of the 1, 4-DHP ring. Diludine and DHPs of group 3 exerted antiradical activities, unlike compounds of group 2. However, novel DHPs had cell type and concentration dependent effects on 3H-thymidine incorporation, while diludine did not. Hence, IB-32 (group 2) suppressed the growth of HOS and HeLa, enhancing growth of L929 cells, while K-2-11 (group 3) enhanced growth of every cell line tested, even in the presence of doxorubicin. Therefore, growth regulating and antiradical activity principles of novel DHPs should be further studied to find if DHPs of group 2 could selectively suppress cancer growth and if those of group 3 promote wound healing.

dihydropyridine derivatives ; cell growth ; antiradical activity

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Podaci o izdanju

2017

2017.

4069839-1-4069839-15

objavljeno

1942-0900

10.1155/2017/4069839

Povezanost rada

nije evidentirano

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