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Pregled bibliografske jedinice broj: 884307

Časopis

Autori: Senta, Ivan; Krizman, Ivona; Terzić, Senka; Ahel, Marijan
Naslov: Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry
( Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry )
Izvornik: Journal of chromatography. A (0021-9673) 1509 (2017); 60-68
Vrsta rada: članak
Ključne riječi: Antibiotics ; Azithromycin ; Erythromycin ; Clarithromycin ; Transformation products ; Liquid chromatography–tandem mass spectrometry ; Wastewater ; Surface water
( Antibiotics ; Azithromycin ; Erythromycin ; Clarithromycin ; Transformation products ; Liquid chromatography–tandem mass spectrometry ; Wastewater ; Surface water )
Sažetak:
Macrolide antibiotics are a prominent group of emerging contaminants frequently found in wastewater effluents and wastewater-impacted aquatic environments. In this work, a novel analytical method for simultaneous determination of parent macrolide antibiotics (azithromycin, erythromycin, clarithromycin and roxithromycin), along with their synthesis intermediates, byproducts, metabolites and transformation products in wastewater and surface water was developed and validated. Samples were enriched using solid-phase extraction on Oasis HLB cartridges and analyzed by reversed-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry. The target macrolide compounds were separated on an ACE C18 PFP column and detected using multiple reaction monitoring in positive ionization polarity. The optimized method, which included an additional extract clean-up on strong anion-exchange cartridges (SAX), resulted in high recoveries and accuracies, low matrix effects and improved chromatographic separation of the target compounds, even in highly complex matrices, such as raw wastewater. The developed method was applied to the analysis of macrolide compounds in wastewater and river water samples from Croatia. In addition to parent antibiotics, several previously unreported macrolide transformation products and/or synthesis intermediates were detected in municipal wastewater, some of them reaching μg/L levels. Moreover, extremely high concentrations of macrolides up to mg/L level were found in pharmaceutical industry effluents, indicating possible importance of this source to the total loads into ambient waters. The results revealed a significant contribution of synthesis intermediates and transformation products to the overall mass balance of macrolides in the aquatic environment.
Projekt / tema: HRZZ-IP-2014-09-7031
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Geologija,Kemija
Puni text rada: 884307.Senta_et_al_JCA_2017.pdf (tekst priložen 5. Srp. 2017. u 14:46 sati)
URL Internet adrese: https://doi.org/10.1016/j.chroma.2017.06.005
http://www.sciencedirect.com/science/article/pii/S0021967317308385?via%3Dihub
Broj citata:
Altmetric:
DOI: 10.1016/j.chroma.2017.06.005
URL cjelovitog teksta:
Google Scholar: Comprehensive determination of macrolide antibiotics, their synthesis intermediates and transformation products in wastewater effluents and ambient waters by liquid chromatography- tandem mass spectrometry
Upisao u CROSBI: Senka Terzić (Senka.Terzic@irb.hr), 5. Srp. 2017. u 14:46 sati



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