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Ganglioside expression in tissues of mice lacking beta2-microglobulin (CROSBI ID 95734)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Markotić, Anita ; Marušić, Ana ; Tomac, Jelena ; Müthing, Johannes Ganglioside expression in tissues of mice lacking beta2-microglobulin // Clinical and experimental immunology, 128 (2002), 27-35-x

Podaci o odgovornosti

Markotić, Anita ; Marušić, Ana ; Tomac, Jelena ; Müthing, Johannes

engleski

Ganglioside expression in tissues of mice lacking beta2-microglobulin

This study presents a comparative analysis of gangliosides from lymphoid (spleen and thymus) and other (brain, liver, lungs and muscle) tissues of C57BL/6 mice lacking the gene for beta2-microglobulin (beta2M), a constitutive component of the MHC class I molecule. Ganglioside fractions in the tissues of mice homozygous (beta2M-/-) and heterozygous (beta2M-/+) for the gene deletion were determined by high performance thin-layer chromatography (HPTLC), followed by immunostaining with specific polyclonal antibodies. Ubiquitous gangliosides GM3(Neu5Ac) and GM3(Neu5Gc) were the dominant gangliosides in the lungs of the control beta2M-/+ mice, whereas the homozygous knockout mice had substantially decreased expression of these structures. The lungs of the beta2M-/- mice also had reduced expression of T-lymphocyte-specific GM1b-type gangliosides (GM1b and GalNAc-GM1b). beta2M-deficient mice also had more GM1a and GD1a gangliosides in the liver, and several neolacto-series gangliosides were increased in the brain and lungs. This study provides in vivo evidence that the beta2M molecule can influence the acquisition of a distinct ganglioside assembly in different mouse organs, implicating its non-immunological functions.

GSL; B2 microgolobulin; knockout

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Podaci o izdanju

128

2002.

27-35-x

objavljeno

0009-9104

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost