crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 894707

Zbornik radova

Autori: Štimac, Adela; Lapić, Jasimina; Blasina, Valentino; Lukinac, Marija; Djakovic, Senka; Crnolatac, Ivo; Frkanec, Leo; Frkanec, Ruža
Naslov: Adamantanski derivati ferocena: utjecaj na modelne lipidne membrane i antioksidacijska svojstva
Izvornik: 25th CROATIAN MEETING OF CHEMISTS AND CHEMICAL ENGINEERS with international participation and 3rd symposium “VLADIMIR PRELOG”Zagreb : HKD ; HKDI , 2017. 207-207.
Skup: 25th CROATIAN MEETING OF CHEMISTS AND CHEMICAL ENGINEERS with international participation and 3rd symposium “VLADIMIR PRELOG”
Mjesto i datum: Poreč, Hrvatska, 19.-22.04.2017.
Ključne riječi: adamantanski feroceni. membranska fluidnost, liposomi, antioksidansi, DSC, fluorescentna anizotropija
Sažetak:
The aim of this study was to design and synthesize new adamantyl derivatives of ferrocene and explore their effects on fluidity of model lipid membranes as well as their antioxidant abilities. Homoannularly and heteroannularly substituted adamantyl derivatives of ferrocene, were synthesized and incorporated into liposomes. Differential scanning calorimetry and fluorescence anisotropy measurements were employed for investigation of membrane fluidity. The liposomes have been described as an artificial model membrane system and are often used for different biochemical and biophysical studies [1, 2]. In our previous investigations dealing with the synthesis of adamantane derivatives and investigations of liposomes as drug delivery systems as well as model membranes we have demonstrated the significance of the interaction of adamantane molecule and phospholipids in lipids bilayer [3- 5]. Recent studies have shown the wide application of ferrocene as a structural feature in organic and medicinal chemistry [5]. The obtained results have shown that the adamantyl derivatives of ferrocene significantly affect the structure of the lipid bilayer and cause decrease in membrane fluidity. The antioxidant potential of synthesized compounds was assessed using DPPH method and it was shown that examined compounds possess considerable antioxidant activity. In conclusion, results of preliminary investigations have demonstrated that the adamantyl derivatives of ferrocene possess certain activities and justify further research of their potential biomedical application.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: HRZZ-IP-2013-11-7387
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://25hskiki.org/wp-content/uploads/2017/05/25HSKIKI-Book_of_abstracts_web.pdf
Upisao u CROSBI: Adela Štimac (astimac@unizg.hr), 28. Ruj. 2017. u 09:45 sati



Verzija za printanje   za tiskati


upomoc
foot_4