Adamantyl derivatives of ferrocene: their effect on the model lipid membranes and their antioxidant abilities (CROSBI ID 652257)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Štimac, Adela ; Lapić, Jasimina ; Blasina, Valentino ; Lukinac, Marija ; Djakovic, Senka ; Crnolatac, Ivo ; Frkanec, Leo ; Frkanec, Ruža
engleski
Adamantyl derivatives of ferrocene: their effect on the model lipid membranes and their antioxidant abilities
The aim of this study was to design and synthesize new adamantyl derivatives of ferrocene and explore their effects on fluidity of model lipid membranes as well as their antioxidant abilities. Homoannularly and heteroannularly substituted adamantyl derivatives of ferrocene, were synthesized and incorporated into liposomes. Differential scanning calorimetry and fluorescence anisotropy measurements were employed for investigation of membrane fluidity. The liposomes have been described as an artificial model membrane system and are often used for different biochemical and biophysical studies [1, 2]. In our previous investigations dealing with the synthesis of adamantane derivatives and investigations of liposomes as drug delivery systems as well as model membranes we have demonstrated the significance of the interaction of adamantane molecule and phospholipids in lipids bilayer [3- 5]. Recent studies have shown the wide application of ferrocene as a structural feature in organic and medicinal chemistry [5]. The obtained results have shown that the adamantyl derivatives of ferrocene significantly affect the structure of the lipid bilayer and cause decrease in membrane fluidity. The antioxidant potential of synthesized compounds was assessed using DPPH method and it was shown that examined compounds possess considerable antioxidant activity. In conclusion, results of preliminary investigations have demonstrated that the adamantyl derivatives of ferrocene possess certain activities and justify further research of their potential biomedical application.
adamantyl ferrocene ; membrane fluidity ; liposomes ; antioxidants ; DSC ; fluorescence anisotropy
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Podaci o prilogu
207-207.
2017.
objavljeno
Podaci o matičnoj publikaciji
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog : knjiga sažetaka = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog” : Book of Abstracts
Šantić, Ana ; Đaković, Marijana
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo
978-953-552327-7
Podaci o skupu
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog”
poster
12.04.2017-22.04.2017
Poreč, Hrvatska