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Pregled bibliografske jedinice broj: 898283

Časopis

Autori: Vukušić, Kruno; Buđa, Renata; Bosilj, Agneza; Milas, Ana; Pavin, Nenad; Tolić, Iva Marija
Naslov: Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
Izvornik: Developmental cell (1534-5807) 43 (2017), 1; 11-23e6
Vrsta rada: članak
Ključne riječi: mitotic spindle, laser ablation, kinetochore microtubules, overlap microtubules, chromosome segregation, anaphase, bridging microtubules, anaphase model, pole separation, mitosis
Sažetak:
During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinetochores. What forces drive chromosome segregation in anaphase remains a central question. The current model for anaphase in human cells includes shortening of kinetochore fibers and separation of spindle poles. Both processes require kinetochores to be linked with the poles. Here we show, by combining laser ablation, photoactivation, and theoretical modeling, that kinetochores can separate without any attachment to one spindle pole. This separation requires the bridging fiber, a microtubule bundle that connects sister kinetochore fibers. Bridging fiber microtubules in intact spindles slide apart with kinetochore fibers, indicating strong crosslinks between them. We conclude that sliding of microtubules within the bridging fibers drives pole separation and pushes kinetochore fibers poleward by the friction of passive crosslinks between these fibers. Thus, sliding within the bridging fiber works together with the shortening of kinetochore fibers to segregate chromosomes.
Projekt / tema: EK-H2020-647077
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Fizika,Biologija
URL Internet adrese: https://doi.org/10.1016/j.devcel.2017.09.010
https://www.sciencedirect.com/science/article/pii/S1534580717307335
http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30733-5
Broj citata:
Altmetric:
DOI: 10.1016/j.devcel.2017.09.010
URL cjelovitog teksta: https://doi.org/10.1016/j.devcel.2017.09.010
Google Scholar: Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
Upisao u CROSBI: Kruno Vukušić (Kruno.Vukusic@irb.hr), 13. Lis. 2017. u 11:22 sati



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