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Pregled bibliografske jedinice broj: 904947

Časopis

Autori: Mlakar, Marina; Cuculić, Vlado; Frka, Sanja; Gašparović, Blaženka
Naslov: Copper-phospholipid interaction at cell membrane model hydrophobic surfaces
Izvornik: Bioelectrochemistry (Amsterdam) (1567-5394) 120 (2018), C; 10-17
Vrsta rada: članak
Ključne riječi: Phospholipid membrane ; Copper (II) mixed ligand complex ; Voltammetry Langmuir monolayer ; Electrophoretic zeta potential
Sažetak:
Detailed investigation of Cu (II) binding with natural lipid phosphatidylglycerol (PG) in aqueous solution was carried out by voltammetric measurements at the mercury drop electrode, complemented by monolayer studies in a Langmuir trough and electrophoretic measurements, all used as models for hydrophobic cell membranes. Penetration of copper ions into the PG layer was facilitated by the formation of hydrophilic Cu- Phenanthroline (Phen) complex in the subphase, followed by the mixed ligand Cu-Phen-PG complex formation at the hydrophobic interface. Electrophoretic measurements indicated a comparatively low abundance of the formed mixed ligand complex within the PG vesicles, resulting it the zeta potential change of + 0.83 mV, while monolayer studies confirmed their co-existence at the interface. The Cu- Phen-PG complex was identified in the pH range from 6 to 9. The stoichiometry of the complex ([PhenCuOHPG]), as well as its stability and kinetics of formation, were determined at the mercury drop electrode. Cu-Phen-PG reduces quasireversibly at about − 0.7 V vs. Ag/AgCl including reactant adsorption, followed by irreversible mixed complex dissociation, indicating a two-electron transfer - chemical reaction (EC mechanism). Consequently, the surface concentration (γ) of the adsorbed [PhenCuOHPG] complex at the hydrophobic electrode surface was calculated to be (3.35 ± 0.67) × 10− 11 mol cm− 2. Information on the mechanism of Cu (II) - lipid complex formation is a significant contribution to the understanding of complex processes at natural cell membranes.
Projekt / tema: HRZZ-IP-2013-11-8607
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Interdisciplinarne prirodne znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1567539417303250
Broj citata:
Altmetric:
DOI: 10.1016/j.bioelechem.2017.11.004
URL cjelovitog teksta:
Google Scholar: Copper-phospholipid interaction at cell membrane model hydrophobic surfaces
Upisao u CROSBI: Vlado Cuculić (Vlado.Cuculic@irb.hr), 13. Stu. 2017. u 08:27 sati



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