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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 914657

Časopis

Autori: Andrišić, Luka; Dudzik, Danuta; Barbas, Coral; Milković, Lidija; Grune, Tilman; Žarković, Neven
Naslov: Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer
Izvornik: Redox Biology (2213-2317) 14 (2018); 47-58
Vrsta rada: pregledni rad
Ključne riječi: Carcinogenesis, Cancer, Oxidative stress, Lipid peroxidation, 4-hydroxynonenal, Glutathione, Metabolomics, Immunochemistry, Biomarkers, Omics science
Sažetak:
Association of oxidative stress with carcinogenesis is well known, but not understood well, as is pathophysiology of oxidative stress generated during different types of anti-cancer treatments. Moreover, recent findings indicate that cancer associated lipid peroxidation might eventually help defending adjacent nonmalignant cells from cancer invasion. Therefore, untargeted metabolomics studies designed for advanced translational and clinical studies are needed to understand the existing paradoxes in oncology, including those related to controversial usage of antioxidants aiming to prevent or treat cancer. In this short review we have tried to put emphasis on the importance of pathophysiology of oxidative stress and lipid peroxidation in cancer development in relation to metabolic adaptation of particular types of cancer allowing us to conclude that adaptation to oxidative stress is one of the main driving forces of cancer pathophysiology. With the help of metabolomics many novel findings are being achieved thus encouraging further scientific breakthroughs. Combined with targeted qualitative and quantitative methods, especially immunochemistry, further research might reveal bio-signatures of individual patients and respective malignant diseases, leading to individualized treatment approach, according to the concepts of modern integrative medicine.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://fulir.irb.hr/3844/1/AndrisicL_RedoxBiology_14_2018_47.pdf
www.sciencedirect.com/science/article/pii/S2213231717305451
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583394/
Broj citata:
Altmetric:
DOI: 10.1016/j.redox.2017.08.009
URL cjelovitog teksta: www.sciencedirect.com/science/article/pii/S2213231717305451
Google Scholar: Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer
Upisao u CROSBI: Lidija Milković (Lidija.Milkovic@irb.hr), 22. Pro. 2017. u 14:27 sati



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