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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 916496

Časopis

Autori: Wallin, A.; Kapaki, E.; Boban, M.; Engelborghs, S.; Hermann, D. M.; Huisa, B.; Jonsson, M.; Kramberger, M. G.; Lossi, L.; Malojcic, B.; Mehrabian, S.; Merighi, A.; Mukaetova-Ladinska, E. B.; Paraskevas, G. P.; Popescu, B. O.; Ravid, R.; Traykov, L.; Tsivgoulis, G.; Weinstein, G.; Korczyn, A.; Bjerke, M.; Rosenberg, G.
Naslov: Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report
( Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report )
Izvornik: BMC neurology (1471-2377) 17 (2017), 1; 102-114
Vrsta rada: članak
Ključne riječi: Alzheimer’s disease ; Biomarkers ; Blood ; CSF ; Dementia ; Mixed type dementia ; Subcortical small vessel disease ; Vascular cognitive impairment
( Alzheimer’s disease ; Biomarkers ; Blood ; CSF ; Dementia ; Mixed type dementia ; Subcortical small vessel disease ; Vascular cognitive impairment )
Sažetak:
BACKGROUND: Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emerging as a major homogeneous subtype. Its progressive course raises the need for biomarker identification and/or development for adequate therapeutic interventions to be tested. In order to shed light in the current status on biochemical markers for VCI-SSVD, experts in field reviewed the recent evidence and literature data. METHOD: The group conducted a comprehensive search on Medline, PubMed and Embase databases for studies published until 15.01.2017. The proposal on current status of biochemical markers in VCI- SSVD was reviewed by all co- authors and the draft was repeatedly circulated and discussed before it was finalized. RESULTS: This review identifies a large number of biochemical markers derived from CSF and blood. There is a considerable overlap of VCI-SSVD clinical symptoms with those of Alzheimer's disease (AD). Although most of the published studies are small and their findings remain to be replicated in larger cohorts, several biomarkers have shown promise in separating VCI-SSVD from AD. These promising biomarkers are closely linked to underlying SSVD pathophysiology, namely disruption of blood-CSF and blood-brain barriers (BCB-BBB) and breakdown of white matter myelinated fibres and extracellular matrix, as well as blood and brain inflammation. The leading biomarker candidates are: elevated CSF/blood albumin ratio, which reflects BCB/BBB disruption ; altered CSF matrix metalloproteinases, reflecting extracellular matrix breakdown ; CSF neurofilment as a marker of axonal damage, and possibly blood inflammatory cytokines and adhesion molecules. The suggested SSVD biomarker deviations contrasts the characteristic CSF profile in AD, i.e. depletion of amyloid beta peptide and increased phosphorylated and total tau. CONCLUSIONS: Combining SSVD and AD biomarkers may provide a powerful tool to identify with greater precision appropriate patients for clinical trials of more homogeneous dementia populations. Thereby, biomarkers might promote therapeutic progress not only in VCI-SSVD, but also in AD.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)
URL Internet adrese: https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-017-0877-3
Broj citata:
Altmetric:
DOI: 10.1186/s12883-017-0877-3
URL cjelovitog teksta: https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-017-0877-3
Google Scholar: Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report
Upisao u CROSBI: Marina Boban (marina.boban@mef.hr), 5. Sij. 2018. u 23:23 sati



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