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Pregled bibliografske jedinice broj: 925011

Zbornik radova

Autori: Husak, Antonija; Basarić, Nikola
Naslov: Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors
Izvornik: CECP 2018 - Central European Coference on PhotochemistryBad Hofgastein :
Skup: CECP 2018 - Central European Coference on Photochemistry
Mjesto i datum: Bad Hofgastein, 04-08.02.2018.
Ključne riječi: peptides, tryptophan, quinone methides, photodeamination, DNA binding
Sažetak:
Quinone methides (QMs) are reactive intermediates in the chemistry and photochemistry of phenols involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking [1]. Furthermore, it has been demonstrated that QMs exhibit antiproliferative activity, showing potential to be developed into anticancer drugs [2]. One strategy to enhance QMs reactivity with DNA and their antiproliferative activity is to bind the QM precursors to DNA intercallators [3]. We have recently demonstrated that modified tyrosine incorporated in oligopeptides can deliver QMs in the photochemical deamination reaction [3]. Herein we present photophysical properties and photochemical reactivity of tripeptide 1 that contains QM precursor - modified tyrosine and the TrpTrp dipeptide. The TrpTrpTyr sequence was chosen due to its known DNA binding ability [4], as well as fluorescent properties of Trp. Non-covalent and covalent binding of tripeptide 1 to DNA was assayed by fluorescence and CD titrations and by irradiations in the presence of DNA, respectively.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: HRZZ-IP-2014-09-6312
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: Enidija Lukša (Enidija.Luksa@irb.hr), 13. Vel. 2018. u 09:34 sati



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