Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors (CROSBI ID 658732)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Husak, Antonija ; Basarić, Nikola
engleski
Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors
Quinone methides (QMs) are reactive intermediates in the chemistry and photochemistry of phenols involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking [1]. Furthermore, it has been demonstrated that QMs exhibit antiproliferative activity, showing potential to be developed into anticancer drugs [2]. One strategy to enhance QMs reactivity with DNA and their antiproliferative activity is to bind the QM precursors to DNA intercallators [3]. We have recently demonstrated that modified tyrosine incorporated in oligopeptides can deliver QMs in the photochemical deamination reaction [3]. Herein we present photophysical properties and photochemical reactivity of tripeptide 1 that contains QM precursor - modified tyrosine and the TrpTrp dipeptide. The TrpTrpTyr sequence was chosen due to its known DNA binding ability [4], as well as fluorescent properties of Trp. Non- covalent and covalent binding of tripeptide 1 to DNA was assayed by fluorescence and CD titrations and by irradiations in the presence of DNA, respectively.
peptides ; tryptophan ; quinone methides ; photodeamination ; DNA binding
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Podaci o prilogu
P30-P30.
2018.
objavljeno
Podaci o matičnoj publikaciji
Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts
Bad Hofgastein:
Podaci o skupu
Central European Conference on Photochemistry (CECP 2018)
poster
04.02.2018-08.02.2018
Bad Hofgastein, Austrija